{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:19:16Z","timestamp":1761823156310},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The relationship between central conduction time (CCT) and hemispheric cerebral blood flow (CBF) has been examined in 20 patients presenting with subarachnoid hemorrhage. A total of 63 combined CCT\/CBF recordings were performed at various times throughout the hospital course of these patients, and the findings were correlated to clinical status. The initial-slope index of the CBF (CBF<jats:sub>isi<\/jats:sub>) was found to correlate well with clinical grade, and a gradation in flow was noted between the different neurological grades. Patients in Grades I and II (Hunt and Hess classification) had the highest flows (mean CBF<jats:sub>isi<\/jats:sub> = 47.2 \u00b1 8.1); Grade III patients had intermediate flows (mean CBF<jats:sub>isi<\/jats:sub> = 39.6 \u00b1 7.8); and Grade IV patients had the lowest flows (mean CBF<jats:sub>isi<\/jats:sub> = 32.0 \u00b1 6.4).<\/jats:p>\n<jats:p content-type=\"fine-print\">While CCT tended to become increasingly prolonged with worsening grade, a significant difference could not be demonstrated between Grade I, II, and III patients. Only when Grade IV status was reached was the CCT significantly prolonged. When CBF<jats:sub>isi<\/jats:sub> and CCT were examined, a threshold relationship was noted between CBF<jats:sub>isi<\/jats:sub> and CCT prolongation. At flow values above 30, little change was noted in CCT, and CCT remained in the normal range. However, at flow values below 30, CCT became increasingly prolonged as blood flow diminished. The degree of CCT prolongation appeared to be directly proportional to the degree of blood flow diminution at flows below threshold.<\/jats:p>","DOI":"10.3171\/jns.1985.62.1.0025","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:00Z","timestamp":1241799300000},"page":"25-30","source":"Crossref","is-referenced-by-count":54,"title":["Relationship between hemispheric cerebral blood flow, central conduction time, and clinical grade in aneurysmal subarachnoid hemorrhage"],"prefix":"10.3171","volume":"62","author":[{"given":"Jacob","family":"Rosenstein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Dah-Jium Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Symon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikio","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1161\/01.STR.8.1.51","article-title":"Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia.","volume":"8","author":"Astrup","year":"1977"},{"key":"b2","series-title":"Cerebral Circulation and Metabolism.","first-page":"378","article-title":"Effect of mechanical rCBF reduction on EEG in man","author":"Boysen","year":"1975"},{"key":"b3","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0022-510X(77)90014-4","article-title":"Extracellular potassium activity, evoked potential and tissue blood flow. 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