{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T04:53:11Z","timestamp":1789620791461,"version":"build-2803163510"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The cerebral vasomotor reactivity to arterial hypotension and hypocapnia was studied in 34 patients between the 3rd and 13th day after rupture of an intracranial saccular aneurysm. Using the intra-arterial xenon-133 injection method, regional cerebral blood flow (rCBF) and cerebral metabolic rate of oxygen (CMRO<jats:sub>2<\/jats:sub>) were measured. The intraventricular pressure and cerebrospinal fluid (CSF) lactate and pH levels were determined. The degree of vasospasm was measured on angiograms taken immediately following the rCBF study. The patients were graded clinically according to the system of Hunt and Hess.<\/jats:p>\n<jats:p content-type=\"fine-print\">Cerebral autoregulation was intact in patients in good clinical condition, but was impaired in patients in poor clinical condition. There was a close correlation between the degree of vasospasm and the degree of autoregulatory impairment, which varied from focal disturbances to global impairment. Intracranial hypertension and CSF lactic acidosis were commonly found in association with vasoparalysis. Cerebrovascular response to hyperventilation was generally preserved, although often reduced. During hyperventilation, the cerebral perfusion pressure became elevated, and increases in CMRO<jats:sub>2<\/jats:sub> were often found, even in patients with severe diffuse spasm and cerebral ischemia. The clinical significance of the results in relation to the treatment of delayed cerebral ischemia and to the use of intraoperative induced hypotension is discussed.<\/jats:p>","DOI":"10.3171\/jns.1985.62.1.0059","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:00Z","timestamp":1241799300000},"page":"59-67","source":"Crossref","is-referenced-by-count":143,"title":["Cerebrovascular reactivity in patients with ruptured intracranial aneurysms"],"prefix":"10.3171","volume":"62","author":[{"given":"Bo","family":"Voldby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erna M.","family":"Enevoldsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn T.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Physiol (Lond)","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1113\/jphysiol.1902.sp000911","article-title":"On the local reactions of the arterial wall to changes of internal pressure.","volume":"28","author":"Bayliss","year":"1902"},{"key":"b2","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1136\/jnnp.42.10.892","article-title":"Delayed effects of subarachnoid haemorrhage on cerebral metabolism and the cerebrovascular response to hypercapnia in the primate.","volume":"42","author":"Boisvert","year":"1979"},{"key":"b3","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1007\/BF02464628","article-title":"The reactivity of the spastic arteries.","volume":"5","author":"du Boulay","year":"1973"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3171\/jns.1978.48.5.0689","article-title":"Autoregulation and CO2 responses of cerebral blood flow in patients with acute severe head injury.","volume":"48","author":"Enevoldsen","year":"1978"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"857","DOI":"10.3171\/jns.1981.55.6.0857","article-title":"Effects of profound hypotension on cerebral blood flow during surgery for intracranial aneurysms.","volume":"55","author":"Farrar","year":"1981"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"337","DOI":"10.3171\/jns.1973.39.3.0337","article-title":"Local cerebral blood flow in experimental middle cerebral artery vasospasm.","volume":"39","author":"Fein","year":"1973"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3171\/jns.1972.37.1.0036","article-title":"Regional cerebral blood flow studies in subarachnoid hemorrhage.","volume":"37","author":"Heilbrun","year":"1972"},{"key":"b8","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/ana.410140602","article-title":"Cerebral vasospasm after subarachnoid hemorrhage: an update.","volume":"14","author":"Heros","year":"1983"},{"key":"b9","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1161\/01.RES.18.3.237","article-title":"Regional cerebral blood flow in man determined by intra-arterial injection of radioactive inert gas.","volume":"18","author":"H\u00f8edt-Rasmussen","year":"1966"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"14","DOI":"10.3171\/jns.1968.28.1.0014","article-title":"Surgical risk as related to time of intervention in the repair of intracranial aneurysms.","volume":"28","author":"Hunt","year":"1968"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3171\/jns.1979.50.5.0587","article-title":"Regional cerebral blood flow in patients with ruptured intracranial aneurysms.","volume":"50","author":"Ishii","year":"1979"},{"key":"b12","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1161\/01.STR.13.5.601","article-title":"A primate model of subarachnoid hemorrhage: change in regional cerebral blood flow, autoregulation, carbon dioxide reactivity, and central conduction time.","volume":"13","author":"Jakubowski","year":"1982"},{"key":"b13","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"917","DOI":"10.3171\/jns.1983.59.6.0917","article-title":"An experimental study of the acute stage of subarachnoid hemorrhage.","volume":"59","author":"Kamiya","year":"1983"},{"key":"b14","series-title":"Tohoku J Exp Med","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1620\/tjem.94.407","article-title":"Studies of cerebral hemodynamics in subarachnoid hemorrhage.","volume":"94","author":"Kutsuzawa","year":"1968"},{"key":"b15","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1212\/WNL.15.7.622","article-title":"Cerebral vasomotor paralysis produced by intracranial hypertension.","volume":"15","author":"Langfitt","year":"1965"},{"key":"b16","series-title":"Lancet","first-page":"1113","article-title":"The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain.","volume":"2","author":"Lassen","year":"1966"},{"key":"b17","series-title":"Acta Psychiatr Neurol Scand","first-page":"1","article-title":"Continuous recording and control of ventricular fluid pressure in neurosurgical practice.","volume":"36","author":"Lundberg","year":"1960"},{"key":"b18","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1161\/01.STR.12.1.58","article-title":"Cerebrovascular reactivity and metabolism after subarachnoid hemorrhage in baboons.","volume":"12","author":"Mendelow","year":"1981"},{"key":"b19","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"916","DOI":"10.3171\/jns.1984.60.5.0916","article-title":"Serial measurement of regional cerebral blood flow in patients with SAH using 133Xe inhalation and emission computerized tomography.","volume":"60","author":"Mickey","year":"1984"},{"key":"b20","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"819","DOI":"10.3171\/jns.1977.47.6.0819","article-title":"Cerebral arterial blood flow and aneurysm surgery. Part 2: Induced hypotension and autoregulatory capacity.","volume":"47","author":"Nornes","year":"1977"},{"key":"b21","series-title":"Acta Neurol Scand","first-page":"1","article-title":"Cerebral blood flow methods for measurement regulation, effects of drugs and changes in disease.","volume":"50","author":"Olesen","year":"1974"},{"key":"b22","series-title":"Stroke","first-page":"519","article-title":"Regional cerebral blood flow in man determined by the initial slope of the clearance of intra-arterially injected 133Xe. Theory of the method, normal values, error of measurement, correction for remaining radioactivity, relation to other flow parameters and response to Paco2 changes.","volume":"2","author":"Olesen","year":"1971"},{"key":"b23","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1161\/01.STR.12.6.736","article-title":"Focal cerebral ischemia measured by the intra-arterial 133Xenon method. Limitations of 2-dimensional blood flow measurements.","volume":"12","author":"Olsen","year":"1981"},{"key":"b24","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1212\/WNL.20.1.63","article-title":"Regional cerebral blood flow in apoplexy due to occlusion of the middle cerebral artery.","volume":"20","author":"Paulson","year":"1970"},{"key":"b25","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1212\/WNL.22.3.286","article-title":"Restoration of autoregulation of cerebral blood flow by hypocapnia.","volume":"22","author":"Paulson","year":"1972"},{"key":"b26","series-title":"Etats D\u00e9ficitaires C\u00e9r\u00e9braux Li\u00e9s \u00e0 l'\u00c2ge. Proceedings of the Sixth Bel-Air Symposium.","first-page":"29","article-title":"Regulation of cerebral blood flow in health and disease","author":"Paulson","year":"1980"},{"key":"b27","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1161\/01.STR.5.2.230","article-title":"The effect of graded hypocapnia and hypercapnia on regional cerebral blood flow and cerebral vessel caliber in the rhesus monkey: study of cerebral hemodynamics following subarachnoid hemorrhage and traumatic internal carotid spasm.","volume":"5","author":"Petruk","year":"1974"},{"key":"b28","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1136\/jnnp.42.10.899","article-title":"Late effects of subarachnoid haemorrhage on the response of the primate cerebral circulation to drug-induced changes in arterial blood pressure.","volume":"42","author":"Pickard","year":"1979"},{"key":"b29","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"305","DOI":"10.3171\/jns.1980.53.3.0305","article-title":"Prediction of late ischemic complications after cerebral aneurysm surgery by the intraoperative measurement of cerebral blood flow.","volume":"53","author":"Pickard","year":"1980"},{"key":"b30","series-title":"Zentralbl Neurochir","first-page":"223","article-title":"Cerebral blood flow and metabolism in the acute phase of experimental subarachnoid bleed.","volume":"39","author":"Steiner","year":"1978"},{"key":"b31","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3171\/jns.1982.56.2.0186","article-title":"Intracranial pressure changes following aneurysm rupture. Part 1: Clinical and angiographic correlations.","volume":"56","author":"Voldby","year":"1982"},{"key":"b32","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"197","DOI":"10.3171\/jns.1982.56.2.0197","article-title":"Intracranial pressure changes following aneurysm rupture. Part 2: Associated cerebrospinal fluid lactacidosis.","volume":"56","author":"Voldby","year":"1982"},{"key":"b33","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"784","DOI":"10.3171\/jns.1982.56.6.0784","article-title":"Intracranial pressure changes following aneurysm rupture. Part 3: Recurrent hemorrhage.","volume":"56","author":"Voldby","year":"1982"},{"key":"b34","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3171\/jns.1985.62.1.0048","article-title":"Regional CBF, intraventricular pressure and cerebral metabolism in patients with ruptured intracranial aneurysms.","volume":"62","author":"Voldby","year":"1985"},{"key":"b35","series-title":"Pfluegers Arch","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/BF00586483","article-title":"Micropuncture evaluation of the importance of perivascular pH for the arteriolar diameter on the brain surface.","volume":"316","author":"Wahl","year":"1970"},{"key":"b36","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"173","DOI":"10.3171\/jns.1978.48.2.0173","article-title":"Time course of vasospasm in man.","volume":"48","author":"Weir","year":"1978"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/62\/1\/article-p59.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/62\/1\/article-p59.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/62\/1\/article-p59.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T18:51:45Z","timestamp":1658688705000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/62\/1\/article-p59.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":36,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1985.62.1.0059","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}