{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:32:14Z","timestamp":1772915534100,"version":"3.50.1"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Ten patients with Nelson's syndrome, nine women and one man, aged 22 to 61 years, were treated neurosurgically by a transsphenoidal approach. In four patients, microadenomas were found, ranging in diameter from 4 to 10 mm. Microscopically, mixed adenoma was diagnosed in six cases, basophilic adenoma in three patients, and chromophobe adenoma in one patient. The presence of argyrophilic nerve fibers in the adenoma tissue was noted in one case. The time of observation after transsphenoidal surgery ranged from 6 months to 10 years. Clinical remission was achieved in eight patients; in two of them, radiation therapy was used to complement surgical treatment. In two patients, recurrence of the pituitary neoplasm was observed; anaplasia was revealed at the second operation in one of them. Radiation therapy might be a useful adjunct to neurosurgery in Nelson's syndrome, especially in patients with anaplastic adenoma.<\/jats:p>","DOI":"10.3171\/jns.1985.62.1.0068","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:00Z","timestamp":1241799300000},"page":"68-71","source":"Crossref","is-referenced-by-count":19,"title":["Results of neurosurgical treatment by a transsphenoidal approach in 10 patients with Nelson's syndrome"],"prefix":"10.3171","volume":"62","author":[{"given":"Jerzy","family":"Wis\u0142awski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna A.","family":"Kasperlik-Za\u0142uska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wojciech","family":"Jeske","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Migdalska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jadwiga","family":"Janik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jozef","family":"Za\u0142uska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw","family":"Bonicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"2725","DOI":"10.1172\/JCI105955","article-title":"Radioimmunoassay of ACTH in plasma.","volume":"47","author":"Berson","year":"1968"},{"key":"b2","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1210\/jcem-56-5-985","article-title":"The evaluation of sodium valproate in the treatment of Nelson's syndrome.","volume":"56","author":"Dornhorst","year":"1983"},{"key":"b3","series-title":"Clinical Neuroendocrinology. A Pathophysiological Approach.","first-page":"116","article-title":"Stimulatory effects of endorphins and their analogs on prolactin and growth hormone secretion","author":"Dupont","year":"1979"},{"key":"b4","series-title":"Advances and Technical Standards in Neurosurgery.","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-7091-7080-9_1","article-title":"Surgical problems of pituitary adenomas","volume":"3","author":"Guiot","year":"1976"},{"key":"b5","series-title":"Prog Neurol Surg","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1159\/000397693","article-title":"Trans-sphenoidal microsurgical removal of pituitary micro-adenoma.","volume":"6","author":"Hardy","year":"1975"},{"key":"b6","series-title":"Acta Endocrinol","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1530\/acta.0.0910385","article-title":"The effect of metoclopramide, TRH and L-DOPA on prolactin secretion in pituitary adenoma and in \u201cfunctional\u201d galactorrhoea syndrome.","volume":"91","author":"Jeske","year":"1979"},{"key":"b7","series-title":"Prolactin Secretion in Man in Selected Physiological and Pathological Conditions. Habilitation Project.","author":"Jeske","year":"1979"},{"key":"b8","series-title":"Endokrynol Pol","first-page":"109","article-title":"The radioimmunoassay of total serum thyroxine and triiodothyronine.","volume":"28","author":"Jeske","year":"1977"},{"key":"b9","series-title":"Endokrynol Pol","first-page":"401","article-title":"Nelson's syndrome following bilateral total adrenalectomy.","volume":"27","author":"Kasperlik-Za\u0142uska","year":"1976"},{"key":"b10","series-title":"Clin Endocrinol","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1111\/j.1365-2265.1983.tb00046.x","article-title":"Nelson's syndrome: incidence and prognosis.","volume":"19","author":"Kasperlik-Za\u0142uska","year":"1983"},{"key":"b11","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1210\/jcem-54-2-286","article-title":"Adrenocorticotropin-secreting pituitary adenomas originate from the anterior or the intermediate lobe in Cushing's disease: differences in the regulation of hormone secretion.","volume":"54","author":"Lamberts","year":"1982"},{"key":"b12","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF01405437","article-title":"Evaluation of surgically treated Nelson's syndrome.","volume":"65","author":"L\u00fcdecke","year":"1982"},{"key":"b13","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1210\/endo-79-1-10","article-title":"Radioimmunoassay: a method for human chorionic gonadotropin and human luteinizing hormone.","volume":"79","author":"Midgley","year":"1966"},{"key":"b14","series-title":"Treatment of Pituitary Adenomas.","first-page":"343","article-title":"Diagnosis and treatment of ACTH-producing tumors","author":"M\u00fcller","year":"1978"},{"key":"b15","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1056\/NEJM195807242590403","article-title":"ACTH-producing tumor of the pituitary gland.","volume":"259","author":"Nelson","year":"1958"},{"key":"b16","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1210\/jcem-24-9-875","article-title":"Fluorometric determination of corticosteroids in human blood: comparison of results with the Silber-Porter method.","volume":"24","author":"Steenburg","year":"1964"},{"key":"b17","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1172\/JCI105234","article-title":"Radioimmunoassay of human plasma thyrotropin.","volume":"44","author":"Utiger","year":"1965"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/62\/1\/article-p68.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/62\/1\/article-p68.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/62\/1\/article-p68.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T18:48:08Z","timestamp":1658688488000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/62\/1\/article-p68.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":17,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1985.62.1.0068","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}