{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:19:20Z","timestamp":1767665960320},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The long-term toxic effects of ethyl 2-cyanoacrylate adhesive were evaluated histologically in 25 cats. Fresh medical- or commercial-grade adhesive was introduced transorbitally into the subarachnoid space in the vicinity of the right middle cerebral artery. Three sham-operated animals served as controls. The animals were sacrificed at intervals ranging from 2 days to 6 months. For both medical- and commercial-grade adhesive, neuropathological examination disclosed acute and chronic granulomatous inflammation of the meninges and evidence of severe vascular damage, including vessel wall necrosis, inflammation, thrombosis, and occasionally hemorrhage. Most animals showed cerebral infarcts of variable size in the territories of distribution of the basal arteries which were in contact with adhesive. The results of this study show that ethyl 2-cyanoacrylate is capable of producing severe arterial and parenchymal damage. The risk of its deleterious effects should be weighed against its potential benefits. Clinical experience would suggest that ethyl 2-cyanoacrylate can be used in difficult situations as long as care is taken to protect the brain and local blood vessels.<\/jats:p>","DOI":"10.3171\/jns.1985.62.1.0108","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:00Z","timestamp":1241799300000},"page":"108-114","source":"Crossref","is-referenced-by-count":8,"title":["Neuropathological changes related to the transorbital application of ethyl 2-cyanoacrylate adhesive to the basal cerebral arteries of cats"],"prefix":"10.3171","volume":"62","author":[{"given":"Thomas W.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Umberto","family":"DeGirolami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Crowell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3171\/jns.1962.19.7.0545","article-title":"Nonsuture sealing of a dural substitute utilizing a plastic adhesive, methyl 2-cyanoacrylate.","volume":"19","author":"Albin","year":"1962"},{"key":"b2","series-title":"Second International Congress of Neurological Surgery.","first-page":"E46","article-title":"Coating and reinforcement of intracranial aneurysms with synthetic resins and rubbers","author":"Araki","year":"1961"},{"key":"b3","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1148\/radiology.139.3.6165036","article-title":"Treatment of intracerebral arteriovenous malformations with isobutyl 2-cyanoacrylate: initial clinical experience.","volume":"139","author":"Bank","year":"1981"},{"key":"b4","series-title":"Neurosurgery","first-page":"366","article-title":"Comment on Hood TW, Mastri AR, Chou SN: Neural and vascular tissue reaction to cyanoacrylate adhesives: a further report.","volume":"11","author":"Carton","year":"1982"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"887","DOI":"10.3171\/jns.1962.19.10.0887","article-title":"Patching of intracranial internal carotid artery in man using a plastic adhesive (Eastman 910 adhesive).","volume":"19","author":"Carton","year":"1962"},{"key":"b6","series-title":"J Neurosurg","first-page":"266","article-title":"Use of cyanoacrylates.","volume":"46","author":"Chou","year":"1977"},{"key":"b7","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1093\/neurosurgery\/21.CN_suppl_1.182","article-title":"Technique and material for coating aneurysms.","volume":"21","author":"Chou","year":"1974"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"884","DOI":"10.3171\/jns.1964.21.10.0884","article-title":"Late thrombosis following the use of autogenous fascia and a cyanoacrylate (Eastman 910 monomer) for the wrapping of an intracranial aneurysm.","volume":"21","author":"Coe","year":"1964"},{"key":"b9","series-title":"Arch Surg","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1001\/archsurg.1966.01330030058013","article-title":"Biological substrates and cure rates of cyanoacrylate tissue adhesives.","volume":"93","author":"Collins","year":"1966"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"705","DOI":"10.3171\/jns.1980.52.5.0705","article-title":"Treatment of cerebral arteriovenous malformations. 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