{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:16:46Z","timestamp":1759033006619},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Subarachnoid hemorrhage (SAH) was produced in cats by transorbital rupture of the right middle cerebral artery (MCA). In untreated cats, widespread proliferative angiopathy occurred in both MCA's by 16 days after SAH. In cats that received systemic heparin, the pathological events following SAH were clearly reduced in the ruptured artery, and were not present in the contralateral left MCA. Platelets are known to adhere to the subintimal surface of cerebral arteries after SAH. The authors suggest that platelet-derived growth factor released from the intimal platelet carpet following SAH may be the stimulus for the development of proliferative angiopathy, and that this platelet factor is inhibited by heparin.<\/jats:p>","DOI":"10.3171\/jns.1985.62.4.0570","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:18:30Z","timestamp":1241799510000},"page":"570-575","source":"Crossref","is-referenced-by-count":24,"title":["Heparin reduces proliferative angiopathy following subarachnoid hemorrhage in cats"],"prefix":"10.3171","volume":"62","author":[{"given":"John P.","family":"Kapp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben R.","family":"Clower","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick M.","family":"Azar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyoshi","family":"Yabuno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Angiology","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1177\/000331977602701206","article-title":"A comparison of intimal proliferation in experimental subarachnoid hemorrhage and atherosclerosis.","volume":"27","author":"Alksne","year":"1976"},{"key":"b2","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1161\/01.STR.12.4.501","article-title":"Constrictive endarteropathy following experimental subarachnoid hemorrhage.","volume":"12","author":"Clower","year":"1981"},{"key":"b3","series-title":"Nature","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1038\/265625a0","article-title":"Suppression by heparin of smooth muscle cell proliferation in injured arteries.","volume":"265","author":"Clowes","year":"1977"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3171\/jns.1972.37.6.0715","article-title":"Structural changes of the intradural arteries following subarachnoid hemorrhage.","volume":"37","author":"Conway","year":"1972"},{"key":"b5","series-title":"Brain","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1093\/brain\/87.3.491","article-title":"The pathogenesis of cerebral infarction following the rupture of cerebral berry aneurysms.","volume":"87","author":"Crompton","year":"1964"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"869","DOI":"10.3171\/jns.1981.55.6.0869","article-title":"Subarachnoid hemorrhage and cerebrovascular spasm. 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