{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T20:01:43Z","timestamp":1773950503566,"version":"3.50.1"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Frozen tissue samples were obtained from meningiomas in 42 patients. Both cytosolic and nuclear fractions were tested for estradiol and progestin binding using equilibrium binding assays. The results were correlated with the age of the patient and the histological type and cellular density of the tumor.<\/jats:p>\n<jats:p content-type=\"fine-print\">Cytosolic estradiol binding was noted in 25 (60%) of 42 tumors, with eight (19%) of the 42 having levels over 10 femtomoles (fM)\/mg protein. Nuclear estradiol binding was detected in 16 (57%) of 28 tumors, with six (21%) of the 28 having levels over 10 fM\/mg protein. Cytosolic progestin binding was noted in 16 (73%) of 22 samples, with levels in nine (41%) of 22 being greater than 10 fM\/mg protein. There was no correlation between the level of cytoplasmic progestin binding and either the level of cytoplasmic estradiol binding or the level of nuclear estradiol binding. In several specimens, levels of cytoplasmic progestin binding in excess of 100 fM\/mg protein were found in tissues demonstrating little or no estradiol binding by either the nucleus or the cytosol. This discrepancy differs from the situation found in other hormonally responsive tissues such as breast or uterus, and suggests either a possible derangement of the normal cellular hormonal control mechanism or that the measured hormone binder is a molecule other than a classical hormone receptor.<\/jats:p>","DOI":"10.3171\/jns.1985.62.5.0750","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:57Z","timestamp":1241799357000},"page":"750-756","source":"Crossref","is-referenced-by-count":77,"title":["Estrogen and progestin binding by cytosolic and nuclear fractions of human meningiomas"],"prefix":"10.3171","volume":"62","author":[{"given":"Robert L.","family":"Martuza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas C.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"MacLaughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1136\/jnnp.21.2.89","article-title":"The relapsing course of certain meningiomas in relation to pregnancy and menstruation.","volume":"21","author":"Bickerstaff","year":"1958"},{"key":"b2","series-title":"Eur J Cancer Clin Oncol","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1016\/0277-5379(83)90134-7","article-title":"Presence of progesterone receptors and absence of oestrogen receptors in human intracranial meningioma cytosols.","volume":"19","author":"Blankenstein","year":"1983"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"985","DOI":"10.3171\/jns.1984.60.5.0985","article-title":"Estrogen and progesterone receptors in meningiomas.","volume":"60","author":"Cahill","year":"1984"},{"key":"b4","series-title":"J Steroid Biochem","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/0022-4731(84)90259-0","article-title":"Steroid receptors in CNS: estradiol (ER) and progesterone (PR) receptors in human spinal cord tumors.","volume":"20","author":"Concolino","year":"1984"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"499","DOI":"10.3171\/jns.1979.50.4.0499","article-title":"Estrogen-receptor protein in intracranial meningiomas.","volume":"50","author":"Donnell","year":"1979"},{"key":"b6","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1227\/00006123-198311000-00005","article-title":"Hormone binding in brain tumors.","volume":"13","author":"Glick","year":"1983"},{"key":"b7","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1210\/endo-103-5-1742","article-title":"Estrogen control of progesterone receptor in human breast cancer: role of estradiol and antiestrogen.","volume":"103","author":"Horwitz","year":"1978"},{"key":"b8","series-title":"Cell","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/0092-8674(82)90218-5","article-title":"Variant T47D human breast cancer cells with high progesterone-receptor levels despite estrogen and antiestrogen resistance.","volume":"28","author":"Horwitz","year":"1982"},{"key":"b9","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1002\/1097-0142(19810515)47:10<2319::AID-CNCR2820471002>3.0.CO;2-X","article-title":"Hormone dependency of breast cancer.","volume":"47","author":"Jensen","year":"1981"},{"key":"b10","series-title":"Natl Cancer Inst Monogr","first-page":"55","article-title":"Estrogen receptors and breast cancer response to adrenalectomy.","volume":"34","author":"Jensen","year":"1971"},{"key":"b11","series-title":"J Recept Res","doi-asserted-by":"publisher","first-page":"215","DOI":"10.3109\/10799898009044099","article-title":"Estrogens and the hypothalamus: nuclear receptor and RNA polymerase activation.","volume":"1","author":"Kelner","year":"1980"},{"key":"b12","series-title":"J Biol Chem","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent.","volume":"193","author":"Lowry","year":"1951"},{"key":"b13","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/BF01406053","article-title":"Progestin and oestrogen receptors in meningiomas. 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