{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:59:09Z","timestamp":1776823149259,"version":"3.51.2"},"reference-count":23,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,9]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Hyponatremia developing some days after transsphenoidal pituitary adenectomy is a treacherous complication of uncertain cause. Of 19 patients monitored in a pilot study at the Wessex Neurological Centre, plasma sodium fell below 125 mmol\/liter in three patients at times ranging from 6 to 9 days postoperatively. One patient had evidence of inappropriate secretion of arginine vasopressin (AVP), and the other two probably had steroid insufficiency despite apparently adequate steroid cover. In a more detailed study, the fluid and sodium balance of a further 16 patients was monitored for 7 to 11 days following transsphenoidal surgery together with plasma cortisol, renin, and AVP concentrations. No patient became severely hyponatremic. Three developed partial diabetes insipidus. Two patients with Cushing's disease had evidence of postoperative corticosteroid insufficiency despite normal steroid protection. An inappropriately low plasma cortisol concentration was recorded in both. Plasma AVP concentrations did not show a delayed surge postoperatively. Delayed hyponatremia appears to occur most often in patients with hypoadrenalism, as glucocorticoid cover is decreased. It results from water retention combined with natriuresis, and is reversed by glucocorticoid treatment.<\/jats:p>","DOI":"10.3171\/jns.1985.63.3.0404","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:20:32Z","timestamp":1241799632000},"page":"404-412","source":"Crossref","is-referenced-by-count":24,"title":["Fluid balance and secretion of antidiuretic hormone following transsphenoidal pituitary surgery"],"prefix":"10.3171","volume":"63","author":[{"given":"Stephen J.","family":"Whitaker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin I.","family":"Meanock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian F.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J.","family":"Smythe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Pickard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan R.","family":"Noble","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Br J Hosp Med","first-page":"860","article-title":"Metabolic aspects of intensive care.","volume":"11","author":"Allison","year":"1974"},{"key":"b2","first-page":"1192","article-title":"Posterior pituitary: antidiuretic hormone","author":"Andreoli","year":"1982"},{"key":"b3","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1210\/jcem-25-11-1481","article-title":"Measurement of the osmotic threshold for vasopressin release in human subjects, and its modification by cortisol.","volume":"25","author":"Aubry","year":"1965"},{"key":"b4","series-title":"Drug Intelligence Clinical Pharmacy","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1177\/106002808301701202","article-title":"Drug management of antidiuretic hormone imbalance following pituitary surgery.","volume":"17","author":"Benzie","year":"1983"},{"key":"b5","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1210\/jcem-50-2-348","article-title":"Cushing's disease: management by transsphenoidal pituitary microsurgery.","volume":"50","author":"Bigos","year":"1980"},{"key":"b6","series-title":"J Clin Invest","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1172\/JCI109184","article-title":"Role of plasma vasopressin in impaired water excretion of glucocorticoid deficiency.","volume":"62","author":"Boykin","year":"1978"},{"key":"b7","series-title":"The Pituitary Adenoma.","first-page":"417","article-title":"Endocrine management after pituitary surgery","author":"Cobb","year":"1980"},{"key":"b8","series-title":"Lancet","first-page":"752","article-title":"Cerebral salt wasting.","volume":"1","author":"Cort","year":"1954"},{"key":"b9","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1056\/NEJM198407053110107","article-title":"Inappropriate secretion of antidiuretic hormone after transsphenoidal surgery for pituitary tumors.","volume":"311","author":"Cusick","year":"1984"},{"key":"b10","series-title":"Hormones in Blood","first-page":"423","article-title":"Vasopressin","volume":"2","author":"Edwards","year":"1979"},{"key":"b11","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1210\/jcem-54-2-413","article-title":"Cushing's disease: transient secondary adrenal insufficiency after selective removal of pituitary microadenomas; evidence for a pituitary origin.","volume":"54","author":"Fitzgerald","year":"1982"},{"key":"b12","series-title":"Manual of Clinical Endocrinology and Metabolism.","first-page":"37","author":"Griffin","year":"1982"},{"key":"b13","series-title":"Arch Surg","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1001\/archsurg.1978.01370170059011","article-title":"Radioimmunoassayable plasma vasopressin associated with surgery.","volume":"113","author":"Haas","year":"1978"},{"key":"b14","series-title":"J Clin Endocrinol Metab","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1210\/jcem-55-3-551","article-title":"Steroid replacement in Addison's disease and in subjects adrenalectomized for Cushing's disease: comparison of various glucocorticoids.","volume":"55","author":"Khalid","year":"1982"},{"key":"b15","series-title":"Lancet","first-page":"153","article-title":"Postoperative water and sodium retention.","volume":"1","author":"Le Quesne","year":"1953"},{"key":"b16","series-title":"Am J Med","first-page":"200","article-title":"Potency and duration of action of glucocorticoids. 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