{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T20:16:48Z","timestamp":1694636208098},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Of 243 patients who underwent intracranial pressure (ICP) monitoring after severe head injury, 42 (17%) were found to have severe persistently raised ICP, in spite of hyperventilation, mannitol, and surgical decompression. Althesin was infused to reduce ICP in these patients. This agent was shown to be effective and safe in reducing ICP, and a significant improvement in cerebral perfusion pressure was demonstrated. In this respect, Althesin may be more effective than barbiturates. However, no improvement in patient outcome was demonstrated in this series.<\/jats:p>","DOI":"10.3171\/jns.1986.64.3.0414","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:08Z","timestamp":1241799308000},"page":"414-419","source":"Crossref","is-referenced-by-count":4,"title":["Experience with Althesin in the management of persistently raised ICP following severe head injury"],"prefix":"10.3171","volume":"64","author":[{"given":"Ross","family":"Bullock","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"van Dellen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Gustav","family":"Reinach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Pathol","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/jcp.33.12.1132","article-title":"Brain damage in fatal non-missile head injury.","volume":"33","author":"Adams","year":"1980"},{"key":"b2","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1097\/00000542-197812000-00003","article-title":"Thiopental amelioration of brain damage after global ischemia in monkeys.","volume":"49","author":"Bleyaert","year":"1978"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"170","DOI":"10.3171\/jns.1981.54.2.0170","article-title":"Diffuse cerebral swelling following head injuries in children: the syndrome of \u201cmalignant brain edema.\u201d","volume":"54","author":"Bruce","year":"1981"},{"key":"b4","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1097\/00000542-198410000-00002","article-title":"Regional cerebral glucose utilization during Althesin anesthesia.","volume":"61","author":"Davis","year":"1984"},{"key":"b5","series-title":"Br Med J","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1136\/bmj.2.6089.735","article-title":"Adverse reactions to intravenous anaesthetic induction agents.","volume":"2","author":"Evans","year":"1977"},{"key":"b6","series-title":"Anaesthesia","first-page":"906","article-title":"Sensitivity testing for Althesin.","volume":"34","author":"Fisher","year":"1979"},{"key":"b7","series-title":"Anaesth Intensive Care","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1177\/0310057X8401200203","article-title":"Effect of long-term continuous infusion of alfathesin on clinical, biochemical and haematological parameters.","volume":"12","author":"Gibbs","year":"1984"},{"key":"b8","series-title":"The Pharmacological Basis of Therapeutics","first-page":"102","article-title":"Hypnotics and sedatives. The barbiturates","author":"Harvey","year":"1975"},{"key":"b9","series-title":"Head Injury.","first-page":"276","article-title":"Brain swelling: studies of structural, physiologic, and biochemical alterations","author":"Ishii","year":"1966"},{"key":"b10","series-title":"Lancet","first-page":"480","article-title":"Assessment of outcome after severe brain damage. A practical scale.","volume":"1","author":"Jennett","year":"1975"},{"key":"b11","series-title":"J Cereb Blood Flow Metab","first-page":"S540","article-title":"\u201cProtective\u201d neuroanaesthesia: Althesin induced very low blood flow and metabolism in the brain measured during craniotomy by Kety & Schmidt technique.","volume":"3","author":"Kruse","year":"1983"},{"key":"b12","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3171\/jns.1982.56.1.0019","article-title":"Can the outcome from head injury be improved?","volume":"56","author":"Langfitt","year":"1982"},{"key":"b13","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"26","DOI":"10.3171\/jns.1979.50.1.0026","article-title":"The outcome with aggressive treatment in severe head injuries. Part II: Acute and chronic barbiturate administration in the management of head injury.","volume":"50","author":"Marshall","year":"1979"},{"key":"b14","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1227\/00006123-198301000-00011","article-title":"Althesin in the management of head injuries: a preliminary report.","volume":"12","author":"McIlhany","year":"1983"},{"key":"b15","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1097\/00000542-197409000-00004","article-title":"The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog.","volume":"41","author":"Michenfelder","year":"1974"},{"key":"b16","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/ana.410060302","article-title":"Barbiturates and raised intracranial pressure.","volume":"6","author":"Miller","year":"1979"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3171\/jns.1981.54.3.0289","article-title":"Further experience in the management of severe head injury.","volume":"54","author":"Miller","year":"1981"},{"key":"b18","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"650","DOI":"10.3171\/jns.1982.56.5.0650","article-title":"Intracranial pressure: to monitor or not to monitor? A review of our experience with severe head injury.","volume":"56","author":"Narayan","year":"1982"},{"key":"b19","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1227\/00006123-198304000-00005","article-title":"Barbiturate therapy in uncontrolled intracranial hypertension.","volume":"12","author":"Rea","year":"1983"},{"key":"b20","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1002\/ana.410060303","article-title":"High-dose barbiturate therapy in humans: a clinical review of 60 patients.","volume":"6","author":"Rockoff","year":"1979"},{"key":"b21","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1227\/00006123-198103000-00001","article-title":"Calculated recovery rates in severe head truma.","volume":"8","author":"Salcman","year":"1981"},{"key":"b22","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1093\/bja\/48.6.545","article-title":"Effects of Althesin on cerebral blood flow and oxygen consumption in man.","volume":"48","author":"Sari","year":"1976"},{"key":"b23","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3171\/jns.1982.56.4.0498","article-title":"Effect of intracranial pressure monitoring and aggressive treatment on mortality in severe head injury.","volume":"56","author":"Saul","year":"1982"},{"key":"b24","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1093\/bja\/51.9.861","article-title":"Plasma concentrations of alphaxalone during continuous infusion of Althesin.","volume":"51","author":"Sear","year":"1979"},{"key":"b25","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1093\/bja\/45.10.1057","article-title":"Rapid intraoperative reduction of intracranial pressure with thiopentone.","volume":"45","author":"Shapiro","year":"1973"},{"key":"b26","series-title":"Nonparametric Statistics for the Behavioral Sciences.","first-page":"68","author":"Siegel","year":"1956"},{"key":"b27","series-title":"Postgrad Med J","first-page":"105","article-title":"Studies with Althesin \u2014 a new steroid anaesthetic.","volume":"48","author":"Swerdlow","year":"1972"},{"key":"b28","series-title":"Lancet","first-page":"81","article-title":"Assessment of coma and impaired consciousness. A practical scale.","volume":"2","author":"Teasdale","year":"1974"},{"key":"b29","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"691","DOI":"10.3171\/jns.1984.61.4.0691","article-title":"Absent or compressed basal cisterns on first CT scan: ominous predictors of outcome in severe head injury.","volume":"61","author":"Toutant","year":"1984"},{"key":"b30","series-title":"Can Anaesth Soc J","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1007\/BF03007085","article-title":"The effects of intravenous anaesthetic agents on human neutropil chemiluminescence.","volume":"30","author":"White","year":"1983"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/64\/3\/article-p414.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/64\/3\/article-p414.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/64\/3\/article-p414.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T17:56:38Z","timestamp":1658685398000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/64\/3\/article-p414.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":30,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/jns.1986.64.3.0414","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}