{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:25:15Z","timestamp":1772803515845,"version":"3.50.1"},"reference-count":39,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 An oncolytic effect of hyperthermia in the 42\u00b0 to 43\u00b0C range has been previously demonstrated in cell culture and animal models. To apply this modality clinically, an interstitial microwave antenna array system has been developed for the delivery of controlled hyperthermia to an intracranial tumor volume, and a Phase I clinical trial involving six patients with malignant gliomas was undertaken. The protocol to study technical feasibility and patient tolerance combined interstitial iridium-192 irradiation and interstitial hyperthermia with 60-minute hyperthermia sessions immediately before and after brachytherapy. After-loading catheters suitable for both treatment modalities were implanted using a computerized tomography-assisted technique. Thermometry data confirmed the ability of a microwave antenna system to achieve reliable temperature distributions, and reasonable patient tolerance was documented.<\/jats:p>","DOI":"10.3171\/jns.1986.64.4.0581","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:12:52Z","timestamp":1241799172000},"page":"581-587","source":"Crossref","is-referenced-by-count":74,"title":["Interstitial hyperthermia and iridium brachytherapy in treatment of malignant glioma"],"prefix":"10.3171","volume":"64","author":[{"given":"David W.","family":"Roberts","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence Z.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Fratkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan B.","family":"Douple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W.","family":"Strohbehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Radiat Res","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2307\/3573947","article-title":"Thermally enhanced radioresponse of cultured Chinese hamster cells: inhibition of repair of sublethal damage and enhancement of lethal damage.","volume":"58","author":"Ben-Hur","year":"1974"},{"key":"b2","series-title":"Radiat Res","first-page":"317","article-title":"Ultrasonic hyperthermia: thermal dosimetry and lesion threshold studies in the central nervous system.","volume":"91","author":"Britt","year":"1982"},{"key":"b3","series-title":"Biochem Biophys Res Commun","doi-asserted-by":"publisher","first-page":"1064","DOI":"10.1016\/0006-291X(73)91046-2","article-title":"Thermal enhancement of DNA damage by an alkylating agent in human cells.","volume":"52","author":"Bronk","year":"1973"},{"key":"b4","series-title":"Appl Neurophysiol","first-page":"180","article-title":"Pathologic anatomy and CT correlations in the glioblastoma multiforme.","volume":"46","author":"Burger","year":"1983"},{"key":"b5","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1002\/1097-0142(196709)20:9<1351::AID-CNCR2820200902>3.0.CO;2-#","article-title":"Selective heat sensitivity of cancer cells. 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