{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T17:10:35Z","timestamp":1717521035551},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The long-term clinical outcome is evaluated for 268 patients after chymopapain chemonucleolysis for radicular complaints referrable to documented intervertebral disc disease. The follow-up period for 92% of these patients was 10 years. No complications due to chymopapain toxicity were observed; 80.1% of patients were relieved of their presenting radicular leg pain and 75.1% were employed at a capacity equal to or more strenuous than before injection. Chemonucleolysis was demonstrated to be a safe and effective treatment modality, with long-term results that compare favorably with those of similarly selected patients undergoing open surgical procedures. In the patients whose chymopapain therapy failed, the outcome of subsequent open surgical procedures was not necessarily compromised by prior chemonucleolysis. A higher rate of failure and subsequent surgical intervention was seen in those patients with injections performed soon after an unsuccessful open procedure on the same side and at the same interspace, those with workmen's compensation or litigation pending, those with a history of work-related injury, those whose employment involved heavy manual labor or extensive driving, and those whose preinjection spine x-ray films indicated retrograde spondylolisthesis.<\/jats:p>","DOI":"10.3171\/jns.1986.65.1.0001","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:13:28Z","timestamp":1241799208000},"page":"1-8","source":"Crossref","is-referenced-by-count":9,"title":["The long-term results of chymopapain chemonucleolysis for lumbar disc disease"],"prefix":"10.3171","volume":"65","author":[{"given":"Robert J.","family":"Maciunas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Burton M.","family":"Onofrio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1001\/jama.1937.02780420025007","article-title":"Pain low in the back and \u201csciatica\u201d due to lesions of the intervertebral disks.","volume":"109","author":"Barr","year":"1937"},{"key":"b2","series-title":"AJR","doi-asserted-by":"publisher","first-page":"587","DOI":"10.2214\/ajr.142.3.587","article-title":"CT of lumbar spine disk herniation: correlation with surgical findings.","volume":"142","author":"Firooznia","year":"1984"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"736","DOI":"10.3171\/jns.1986.64.5.0736","article-title":"Correlation of radiological features to failure of lumbar intervertebral disk chemonucleolysis.","volume":"64","author":"Houser","year":"1986"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3171\/jns.1985.62.5.0662","article-title":"Efficacy of chymopapain chemonucleolysis. A long-term review of 105 patients.","volume":"62","author":"Javid","year":"1985"},{"key":"b5","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1001\/jama.1983.03330420035030","article-title":"Safety and efficacy of chymopapain (Chymodiactin) in herniated nucleus pulposus with sciatica. Results of a randomized, double-blind study.","volume":"249","author":"Javid","year":"1983"},{"key":"b6","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1001\/jama.1962.03050110046009","article-title":"Spinal cord tumors simulating protruded intervertebral disks.","volume":"179","author":"Love","year":"1962"},{"key":"b7","series-title":"Sciatica and Chymopapain","author":"McCullough","year":"1983"},{"key":"b8","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1056\/NEJM193408022110506","article-title":"Rupture of the intervertebral disc with involvement of the spinal canal.","volume":"211","author":"Mixter","year":"1934"},{"key":"b9","series-title":"Mayo Clin Proc","first-page":"207","article-title":"Chemonucleolysis \u2014 past and present.","volume":"58","author":"Onofrio","year":"1983"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3171\/jns.1975.42.4.0384","article-title":"Injection of chymopapain into intervertebral discs. Preliminary report on 72 patients with symptoms of disc disease.","volume":"42","author":"Onofrio","year":"1975"},{"key":"b11","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"990","DOI":"10.3171\/jns.1983.59.6.0990","article-title":"Late results of treatment of intervertebral disc disease with chymopapain.","volume":"59","author":"Parkinson","year":"1983"},{"key":"b12","series-title":"JAMA","first-page":"137","article-title":"Enzyme dissolution of the nucleus pulposus in humans.","volume":"187","author":"Smith","year":"1964"},{"key":"b13","series-title":"Clin Orthop","first-page":"42","article-title":"Biochemistry of chymopapain.","volume":"67","author":"Stern","year":"1969"},{"key":"b14","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"182","DOI":"10.2106\/00004623-196850010-00015","article-title":"Low back and sciatic pain. Neurologic changes, surgical treatment, and postoperative evaluation.","volume":"50","author":"Uihlein","year":"1968"},{"key":"b15","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"374","DOI":"10.3171\/jns.1975.42.4.0374","article-title":"Chymopapain treatment of intervertebral disc disease.","volume":"42","author":"Watts","year":"1975"},{"key":"b16","series-title":"Surg Annu","first-page":"317","article-title":"Lumbar discectomy or chemonucleolysis: pros and cons.","volume":"14","author":"Weir","year":"1982"},{"key":"b17","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1001\/jama.1975.03240170016008","article-title":"Chymopapain chemonucleolysis in lumbar disk disease.","volume":"231","author":"Wiltse","year":"1975"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/65\/1\/article-p1.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/65\/1\/article-p1.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/65\/1\/article-p1.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T15:45:37Z","timestamp":1658677537000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/65\/1\/article-p1.xml"}},"subtitle":["Ten-year follow-up results in 268 patients injected at the Mayo Clinic"],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":17,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1986.65.1.0001","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}