{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T13:06:59Z","timestamp":1758632819655},"reference-count":13,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,12]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Ninety-seven patients with supratentorial malignant gliomas who received postoperative radiation therapy and chemotherapy at the University of California, San Francisco, from 1977 through 1984 showed improvement in their follow-up computerized tomography (CT) scans. Twenty-one of these 97 \u201cCT responders\u201d were designated \u201ccomplete responders\u201d because on serial CT scans they had complete disappearance of the tumor mass and contrast enhancement, which had been present postoperatively. In the remaining 76 patients, CT scans showed reduction in the size, but not disappearance, of the lesions, and these were designated \u201cpartial responders.\u201d Fifty-eight partial responders had glioblastoma multiforme (GM); their median survival time was 72 weeks. The median survival time for the 11 complete responders with GM has not yet been achieved, but survival at the 53rd percentile is 172 weeks. Among patients with highly anaplastic astrocytoma, the median survival time was 211 weeks for the 10 complete responders and 125 weeks for the 18 partial responders. Eleven of the 21 complete responders are alive at a median postoperative follow-up time of 163 weeks (range 114 to 470 weeks). Eighteen of these patients had subtotal resection of tumor; three patients had gross total tumor resections, but postoperative CT scans showed evidence of residual or possibly recurrent tumor within 1.5 to 4.5 months. Resolution of the tumor mass and contrast enhancement took 9 to 151 weeks; the time to resolution did not depend upon the configuration of the remaining tumor mass and contrast enhancement after surgery. In this study, patients with malignant gliomas whose CT scans eventually showed sustained complete disappearance of the tumor mass and contrast enhancement had a more favorable prognosis than did patients whose CT scans showed improvement, but not complete disappearance, of the tumor. These CT findings may prove useful in determining the prognosis of patients with malignant gliomas.<\/jats:p>","DOI":"10.3171\/jns.1986.65.6.0799","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:17:54Z","timestamp":1241799474000},"page":"799-806","source":"Crossref","is-referenced-by-count":37,"title":["Computerized tomography in the prognosis of malignant cerebral gliomas"],"prefix":"10.3171","volume":"65","author":[{"given":"Judith","family":"Murovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Turowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles B.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurooncol","first-page":"267","article-title":"Correlation of survival and diagnosis in supratentorial malignant gliomas.","volume":"2","author":"Davis","year":"1984"},{"key":"b2","series-title":"Biometrika","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/biomet\/52.1-2.203","article-title":"A generalized Wilcoxon test for comparing arbitarily singly-censored samples.","volume":"52","author":"Gehan","year":"1965"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3171\/jns.1967.27.5.0388","article-title":"The treatment of glioblastoma multiforme of the brain.","volume":"27","author":"Jelsma","year":"1967"},{"key":"b4","series-title":"Am Stat Assoc J","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations.","volume":"53","author":"Kaplan","year":"1958"},{"key":"b5","series-title":"Evaluation of Chemotherapeutic Agents.","first-page":"191","article-title":"The clinical evaluation of chemotherapeutic agents in cancer","author":"Karnofsky","year":"1949"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"642","DOI":"10.3171\/jns.1980.52.5.0642","article-title":"Prognostic significance of the pretreatment CT scan on time to progression for patients with malignant gliomas.","volume":"52","author":"Levin","year":"1980"},{"key":"b7","series-title":"Cancer Chemother Rep","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration.","volume":"50","author":"Mantel","year":"1966"},{"key":"b8","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1227\/00006123-198011000-00001","article-title":"Survival in glioblastoma: historical perspective.","volume":"7","author":"Salcman","year":"1980"},{"key":"b9","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1227\/00006123-198204000-00007","article-title":"Effect of age and reoperation on survival in the combined modality treatment of malignant astrocytoma.","volume":"10","author":"Salcman","year":"1982"},{"key":"b10","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/BF00496983","article-title":"Computed tomography in the diagnosis and differential diagnosis of glioblastomas. A qualitative study of 295 cases.","volume":"14","author":"Steinhoff","year":"1977"},{"key":"b11","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/BF01401926","article-title":"Statistical analysis of factors affecting survival after glioblastoma multiforme.","volume":"37","author":"Takeuchi","year":"1977"},{"key":"b12","series-title":"Cancer Medicine","first-page":"1603","article-title":"Brain and peripheral nervous system tumors","author":"Walker","year":"1982"},{"key":"b13","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1056\/NEJM198012043032303","article-title":"Randomized comparisons of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery.","volume":"303","author":"Walker","year":"1980"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/65\/6\/article-p799.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/65\/6\/article-p799.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/65\/6\/article-p799.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,24]],"date-time":"2022-07-24T15:19:04Z","timestamp":1658675944000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/65\/6\/article-p799.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12]]},"references-count":13,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.1986.65.6.0799","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1986,12]]}}}