{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T03:07:03Z","timestamp":1788923223672,"version":"build-2803163510"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Forty-three patients with intractable pain received intrathecal morphine delivered by implanted continuous-infusion (Infusaid) or programmable (Medtronic) devices. In 35 patients the pain was due to cancer, and eight patients had chronic nonmalignant pain. The origin of the nonmalignant pain included lumbar arachnoiditis, multiple sclerosis, severe osteoporosis resulting in a thoracic compression fracture, and intractable pain as a consequence of cancer therapy in individuals cured of their disease. Twenty-eight (80%) of the patients with cancer-related pain experienced excellent or good relief. Side effects were rare. Tolerance occurred infrequently and could be managed effectively. The results of this study support earlier studies on the application of chronic intrathecal morphine for intractable cancer pain. These findings also indicate that, in carefully selected patients, nonmalignant pain may be managed satisfactorily with this technique.<\/jats:p>","DOI":"10.3171\/jns.1987.67.2.0182","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:11:28Z","timestamp":1241799088000},"page":"182-186","source":"Crossref","is-referenced-by-count":180,"title":["Chronic intrathecal morphine for intractable pain"],"prefix":"10.3171","volume":"67","author":[{"given":"Richard D.","family":"Penn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith A.","family":"Paice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00007632-198510000-00014","volume":"10","author":"Auld AW","year":"1985","journal-title":"Spine"},{"key":"b2","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00000542-198206000-00014","volume":"56","author":"Coombs DW","year":"1982","journal-title":"Anesthesiology"},{"key":"b3","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1001\/jama.1983.03340170062030","volume":"250","author":"Coombs DW","year":"1983","journal-title":"JAMA"},{"key":"b4","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1097\/00000542-198503000-00028","volume":"62","author":"Coombs DW","year":"1985","journal-title":"Anesthesiology"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.57.3.0360"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.56.6.0803"},{"key":"b7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/1097-0142(19850801)56:3<696::AID-CNCR2820560343>3.0.CO;2-8","volume":"56","author":"Krames ES","year":"1985","journal-title":"Cancer"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.56.2.0241"},{"key":"b9","first-page":"516","volume":"56","author":"Onofrio BM","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.2.0302"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.55.4.0581"},{"key":"b12","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1227\/00006123-198606000-00011","volume":"18","author":"Shetter AG","year":"1986","journal-title":"Neurosurgery"},{"key":"b13","first-page":"559","volume":"3","author":"Ventafridda V","year":"1979","journal-title":"Adv Pain Res Ther"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197902000-00013"},{"key":"b15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0304-3959(81)90633-3","volume":"11","author":"Yaksh TL","year":"1981","journal-title":"Pain"},{"key":"b16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00000542-198106000-00004","volume":"54","author":"Yaksh TL","year":"1981","journal-title":"Anesthesiology"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/67\/2\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/67\/2\/article-p182.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/67\/2\/article-p182.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T02:42:50Z","timestamp":1652496170000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/67\/2\/article-p182.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":16,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.1987.67.2.0182","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}