{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T07:32:53Z","timestamp":1766820773146},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Changes in the response from the cochlear nerve in dogs resulting from cerebellopontine angle (CPA) manipulations were correlated with histological changes in the nerve. The aim of this study was to determine the mechanisms underlying hearing deficits incurred as a result of manipulations in the CPA. Compound action potentials (CAP) were recorded from the cochlear nerve in response to click stimulation before, during, and after cerebellar and eighth nerve retractions were performed under anesthesia. The retractions were carried out to elicit different degrees of change in the latency and waveform of the CAP. About 30 minutes after completion of the manipulations, the dogs were perfused with a fixative and their cochlear nerves and brain stems were prepared for histological studies. The results showed that retraction of the eighth nerve caused a disintegration of the myelin sheath, and there were multiple and extensive foci of petechial hemorrhage and thromboses of the vasa nervorum of the cochlear nerve.<\/jats:p>\n<jats:p content-type=\"fine-print\">In two dogs in which retraction was carried to a point at which the N<jats:sub>2<\/jats:sub> peak of the CAP was abruptly obliterated, there was a separation of the central and peripheral myelin junction (Obersteiner-Redlich (OR) zone) and bleeding from the vasa nervorum at the OR zone. In the dogs in which the changes in the CAP had almost recovered before fixative perfusion, there were petechial hemorrhages within the cochlear nerve trunk, thus showing that improvement of electrophysiological responses may not always correlate with the absence of morphological changes.<\/jats:p>","DOI":"10.3171\/jns.1987.67.2.0244","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:11:28Z","timestamp":1241799088000},"page":"244-249","source":"Crossref","is-referenced-by-count":52,"title":["Cochlear nerve injuries caused by cerebellopontine angle manipulations"],"prefix":"10.3171","volume":"67","author":[{"given":"Tetsuji","family":"Sekiya","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aage R.","family":"M\u00f8ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","first-page":"156","volume-title":"Peripheral Neuropathy","volume":"1","author":"Berthold CH","year":"1984","edition":"2"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.4.0552"},{"key":"b3","first-page":"330","volume-title":"The Peripheral Nerve.","author":"Gamble HF","year":"1976"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1962.19.11.0947"},{"key":"b5","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00418194","volume":"200","author":"Hanson CC","year":"1971","journal-title":"Arch Klin Exp Ohren Nasen Kehlkopfheilkd"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.6.0888"},{"key":"b7","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/978-3-642-67980-3_62","volume-title":"The Cranial Nerves.","author":"Jannetta PJ","year":"1981"},{"key":"b8","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/978-3-642-67980-3_73","volume-title":"The Cranial Nerves.","author":"Jannetta PJ","year":"1981"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198410000-00012"},{"key":"b10","first-page":"217","volume":"43","author":"Lang J","year":"1982","journal-title":"Zentralbl Neurochir"},{"key":"b11","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/0014-4886(83)90313-8","volume":"80","author":"M\u00f8ller AR","year":"1983","journal-title":"Exp Neurol"},{"key":"b12","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1983.59.3.0493"},{"key":"b13","first-page":"171","volume":"17","author":"N\u011bme\u010dek S","year":"1969","journal-title":"Folia Morphol (Praha)"},{"key":"b14","first-page":"158","volume":"2","author":"Obersteiner H","year":"1894","journal-title":"Arb Neurol Inst Wien Univ"},{"key":"b15","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.5.0938"},{"key":"b16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/aja.1001300106","volume":"130","author":"Ross MD","year":"1971","journal-title":"Am J Anat"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.4.0598"},{"key":"b18","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/019459988409200117","volume":"92","author":"Silverstein H","year":"1984","journal-title":"Otolaryngol Head Neck Surg"},{"key":"b19","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/archneurpsyc.1937.02260150085005","volume":"37","author":"Tarlov IM","year":"1937","journal-title":"Arch Neurol Psychiatr"},{"key":"b20","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-7091-7073-1_5","volume-title":"Advances and Technical Standards in Neurosurgery","volume":"4","author":"Ya\u015fargil MG","year":"1977"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/67\/2\/article-p244.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/67\/2\/article-p244.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/67\/2\/article-p244.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T02:42:47Z","timestamp":1652496167000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/67\/2\/article-p244.xml"}},"subtitle":["An electrophysiological and morphological study in dogs"],"short-title":[],"issued":{"date-parts":[[1987,8]]},"references-count":20,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/jns.1987.67.2.0244","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1987,8]]}}}