{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:53:17Z","timestamp":1785865997743,"version":"3.56.0"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,2]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Peritumoral edema is one of the most serious complications of intracranial neoplasms; however, the exact pathogenesis of this condition is still unknown. To explore the effect of macrophages in brain tumors on the pathogenesis of peritumoral edema, 42 specimens of primary or metastatic brain tumors were studied. Frozen sections were examined by an immunoperoxidase staining technique with anti-Leu-M3 monoclonal antibody. Eight of 14 gliomas demonstrated Leu-M3-positive cell (macrophage) infiltration. The two glioblastomas showed a moderate or marked degree of macrophage infiltration. Twelve of 16 meningiomas demonstrated varying degrees of macrophage infiltration. All six metastatic brain tumors exhibited prominent macrophagesin intra- and peritumoral tissues. Four acoustic neurinomas and two hemangioblastomas showed a slight to moderate degree of macrophage infiltration.<\/jats:p><jats:p content-type=\"fine-print\">Excellent correlation was found between the degree of macrophage infiltration seen on immunoperoxidase staining and the peritumoral edema detected on computerized tomography brain scans of patients with supratentorial tumors, especially meningiomas. Macrophages are known to secrete various substances (including arachidonate metabolites) that may interfere with vascular permeability. These data suggest that macrophages infiltrating brain tumors may play an important role in the pathogenesis of peritumoral edema.<\/jats:p>","DOI":"10.3171\/jns.1988.68.2.0259","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:10:11Z","timestamp":1241799011000},"page":"259-265","source":"Crossref","is-referenced-by-count":98,"title":["Immunohistological evaluation of macrophage infiltrates in brain tumors"],"prefix":"10.3171","volume":"68","author":[{"given":"Masamichi","family":"Shinonaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cha Cheng","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masazumi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Kuwabara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1159\/000408230","volume":"27","author":"Bartkowsky HM","year":"1984","journal-title":"Prog Exp Tumor Res"},{"key":"b2","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0046-8177(84)80143-4","volume":"15","author":"Beckstead JH","year":"1984","journal-title":"Hum Pathol"},{"key":"b3","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410190613"},{"key":"b4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/287147a0","volume":"287","author":"Blackwell GJ","year":"1980","journal-title":"Nature"},{"key":"b5","series-title":"Immunology Series","first-page":"439","volume-title":"Mononuclear Phagocyte Biology.","volume":"26","author":"Bonny RJ","year":"1984"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00333435"},{"key":"b7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1227\/00006123-198010000-00009","volume":"7","author":"Challa VR","year":"1980","journal-title":"Neurosurgery"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410130608"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.47.6.579"},{"key":"b10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4049\/jimmunol.130.1.145","volume":"130","author":"Dimitriu-Bona A","year":"1983","journal-title":"J Immunol"},{"key":"b11","first-page":"385","volume":"13","author":"Fine M","year":"1980","journal-title":"Surg Neurol"},{"key":"b12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0008-8749(84)90052-2","volume":"88","author":"Hofman FM","year":"1984","journal-title":"Cell Immunol"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197901)43:1<258::AID-CNCR2820430137>3.0.CO;2-9"},{"key":"b14","first-page":"141","volume":"1","author":"Hossmann KA","year":"1980","journal-title":"Seara Med Neurocir"},{"key":"b15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00702671","volume":"45","author":"Hossman KA","year":"1979","journal-title":"Acta Neuropathol"},{"key":"b16","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1089\/hyb.1983.2.403","volume":"2","author":"Hsu SM","year":"1983","journal-title":"Hybridoma"},{"key":"b17","unstructured":"Kepes JJ:Meningiomas: Biology, Pathology and Differential Diagnosis.New York: Masson, 1982, pp 93\u2013103"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-198603000-00001"},{"key":"b19","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(87)90109-1"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.1007\/BF01743708"},{"key":"b21","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/00005072-198307000-00007","volume":"42","author":"Mirra SS","year":"1983","journal-title":"J Neuropathol Exp Neurol"},{"key":"b22","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1126\/science.6719118","volume":"224","author":"Moskowitz MA","year":"1984","journal-title":"Science"},{"key":"b23","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1056\/NEJM198009113031106","volume":"303","author":"Nathan CF","year":"1980","journal-title":"N Engl J Med"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198403000-00006"},{"key":"b25","unstructured":"Rubinstein LJ:Tumors of the Central Nervous System. 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