{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:54:21Z","timestamp":1785401661519,"version":"3.56.0"},"reference-count":51,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Mean hemispheric cerebral blood flow (CBF) and intracranial pressure (ICP) were measured in 19 severely head-injured patients treated with barbiturate coma. The CBF was calculated from the clearance of tracer substance monitored by extracranial scintillation detectors after intravenous administration of xenon-133. In 11 of the patients cerebral arteriovenous oxygen differences were measured simultaneously. In all patients the effects of pronounced hyperventilation were recorded prior to initiation of barbiturate treatment. A normal CBF response to hyperventilation (\u0394CBF\/\u0394PaCO<jats:sub>2<\/jats:sub> \u2265 1) was obtained in eight patients. In these patients induction of barbiturate coma was accompanied by physiological decreases in CBF and in the calculated cerebral metabolic rate of oxygen (CMRO<jats:sub>2<\/jats:sub>); they also exhibited a rapid and lasting decrease in ICP. A decreased or an abolished CO<jats:sub>2<\/jats:sub> reactivity was recorded (\u0394CBF\/\u0394PaCO<jats:sub>2<\/jats:sub> &lt; 1) in 11 patients. In 10 of these 11 patients the physiological decreases in CBF and CMRO<jats:sub>2<\/jats:sub> were not obtained during barbiturate treatment and the decrease in ICP was transitory. This study demonstrates a correlation between cerebral vasoreactivity, physiological effects of barbiturate therapy, and clinical outcome.<\/jats:p>","DOI":"10.3171\/jns.1988.68.3.0424","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:21:48Z","timestamp":1241799708000},"page":"424-431","source":"Crossref","is-referenced-by-count":176,"title":["Cerebral blood flow, vasoreactivity, and oxygen consumption during barbiturate therapy in severe traumatic brain lesions"],"prefix":"10.3171","volume":"68","author":[{"given":"Carl-Henrik","family":"Nordstr\u00f6m","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Messeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6ran","family":"Sundb\u00e4rg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilhelm","family":"Schal\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ryding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1097\/00000542-196509000-00007","volume":"26","author":"Alexander SC","year":"1965","journal-title":"Anesthesiology"},{"key":"b2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1152\/jappl.1968.24.1.66","volume":"24","author":"Alexander SC","year":"1968","journal-title":"J Appl Physiol"},{"key":"b3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00254341","volume":"9","author":"Bolmsj\u00f6 M","year":"1984","journal-title":"Eur J Nucl Med"},{"key":"b4","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/jnnp.37.4.384","volume":"37","author":"Brodersen P","year":"1974","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"b5","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1978.48.5.0679"},{"key":"b6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1399-6576.1975.tb05407.x","volume":"57","author":"Carlsson C","year":"1975","journal-title":"Acta Anaesth Scand Suppl"},{"key":"b7","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00000542-197803000-00003","volume":"48","author":"Chapman AG","year":"1978","journal-title":"Anesthesiology"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1978.tb01299.x"},{"key":"b9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1977.tb01232.x"},{"key":"b10","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1977.47.5.0699"},{"key":"b11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1471-4159.1975.tb04350.x","volume":"25","author":"Folbergrov\u00e1 J","year":"1975","journal-title":"J Neurochem"},{"key":"b12","first-page":"83","volume-title":"A Basis and Practice of Neuroanaesthesia. Monographs in Anaesthesia","volume":"2","author":"Harp JR","year":"1975"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)92830-5"},{"key":"b14","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.40.3.291"},{"key":"b15","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1172\/JCI101995","volume":"27","author":"Kety SS","year":"1948","journal-title":"J Clin Invest"},{"key":"b16","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1172\/JCI101994","volume":"27","author":"Kety SS","year":"1948","journal-title":"J Clin Invest"},{"key":"b17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/jcbfm.1981.16","volume":"1","author":"Lassen NA","year":"1981","journal-title":"J Cereb Blood Flow Metab"},{"key":"b18","first-page":"1","volume":"36","author":"Lundberg N","year":"1960","journal-title":"Acta Psychiatr Neurol Scand"},{"key":"b19","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1111\/j.1471-4159.1973.tb00283.x","volume":"20","author":"MacMillan V","year":"1973","journal-title":"J Neurochem"},{"key":"b20","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.50.1.0020"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.50.1.0026"},{"key":"b22","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1986.64.2.0231"},{"key":"b23","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1748-1716.1972.tb05248.x","volume":"85","author":"Messeter K","year":"1972","journal-title":"Acta Physiol Scand"},{"key":"b24","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/57.1.120"},{"key":"b25","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1977.47.4.0503"},{"key":"b26","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.54.3.0289"},{"key":"b27","first-page":"195","volume-title":"Cerebral Hypoxia and its Consequences. Advances in Neurology","volume":"26","author":"Myers RE","year":"1979"},{"key":"b28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/00005072-197605000-00011","volume":"35","author":"Myers RE","year":"1976","journal-title":"J Neuropathol Exp Neurol"},{"key":"b29","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1471-4159.1976.tb04487.x","volume":"26","author":"Norberg K","year":"1976","journal-title":"J Neurochem"},{"key":"b30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.STR.9.4.335","volume":"9","author":"Nordstr\u00f6m CH","year":"1978","journal-title":"Stroke"},{"key":"b31","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.61.2.0241"},{"key":"b32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/01.STR.6.3.245","volume":"6","author":"Obrist WD","year":"1975","journal-title":"Stroke"},{"key":"b33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/978-3-642-70054-5_4","volume-title":"Cerebral Blood Flow and Metabolism Measurement.","author":"Obrist WD","year":"1985"},{"key":"b34","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1976.45.3.0292"},{"key":"b35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000384765","volume":"10","author":"Rappaport ZH","year":"1981","journal-title":"Prog Neurol Surg"},{"key":"b36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1227\/00006123-198304000-00005","volume":"12","author":"Rea GL","year":"1983","journal-title":"Neurosurgery"},{"key":"b37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/jcbfm.1981.34","volume":"1","author":"Rehncrona S","year":"1981","journal-title":"J Cereb Blood Flow Metab"},{"key":"b38","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1161\/01.STR.6.2.142","volume":"6","author":"Risberg J","year":"1975","journal-title":"Stroke"},{"key":"b39","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/jcbfm.1984.34","volume":"4","author":"Ryding E","year":"1984","journal-title":"J Cereb Blood Flow Metab"},{"key":"b40","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/01.RES.4.3.245","volume":"4","author":"Sapirstein LA","year":"1956","journal-title":"Circ Res"},{"key":"b41","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1982.56.4.0498"},{"key":"b42","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1017\/S0317167100045960","volume":"11","author":"Schwartz ML","year":"1984","journal-title":"Can J Neurol Sci"},{"key":"b43","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1212\/WNL.22.2.155","volume":"22","author":"Shalit MN","year":"1972","journal-title":"Neurology"},{"key":"b44","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/jcbfm.1981.18","volume":"1","author":"Siesj\u00f6 BK","year":"1981","journal-title":"J Cereb Blood Flow Metab"},{"key":"b45","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1984.60.5.0883"},{"key":"b46","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1097\/00000542-197204000-00015","volume":"36","author":"Smith AL","year":"1972","journal-title":"Anesthesiology"},{"key":"b47","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.6.0841"},{"key":"b48","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1097\/00005373-197212000-00006","volume":"12","author":"Tabaddor K","year":"1972","journal-title":"J Trauma"},{"key":"b49","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)91639-0"},{"key":"b50","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/00003246-198309000-00005","volume":"11","author":"Traeger SM","year":"1983","journal-title":"Crit Care Med"},{"key":"b51","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.3.0383"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/68\/3\/article-p424.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/68\/3\/article-p424.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/68\/3\/article-p424.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T05:20:26Z","timestamp":1652505626000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/68\/3\/article-p424.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,3]]},"references-count":51,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/jns.1988.68.3.0424","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1988,3]]}}}