{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T10:40:07Z","timestamp":1739097607809,"version":"3.37.0"},"reference-count":41,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The effect of endothelium removal on the contractile responses to KCl, hemoglobin, serotonin (5-HT), norepinephrine (NE), prostaglandin (PG)F<jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>, PGD<jats:sub>2<\/jats:sub>, and PGE<jats:sub>2<\/jats:sub>was investigated in canine and rabbit basilar arteries by an isometric tension-recording method. In canine basilar arteries, endothelium removal elevated the dose-response curves to 5-HT, PGF<jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>, and PGD<jats:sub>2<\/jats:sub>, and PGE<jats:sub>2<\/jats:sub>, but not to KCl, hemoglobin, or NE. In rabbit basilar arteries, on the other hand, removal of the endothelium elevated the dose-response curves to 5-HT, NE, PGF<jats:sub>2<jats:italic>\u03b1<\/jats:italic><\/jats:sub>, and PGD<jats:sub>2<\/jats:sub>, but not to KCl or hemoglobin. Neither contractile nor inhibitory response was elicited by PGE<jats:sub>2<\/jats:sub>in rabbit basilar arteries. Contraction induced by 5-HT and NE following endothelium removal had a much more pronounced effect in rabbit basilar arteries than in canine basilar arteries.<\/jats:p><jats:p content-type=\"fine-print\">These results suggest that, following endothelium removal, abolition of the spontaneous release of endothelium-derived relaxing factor is the most probable mechanism of the enhanced vasocontraction. Since endothelial damage results from subarachnoid hemorrhage, the aforementioned mechanism of vasocontractile enhancement may play a role in the pathogenesis of cerebral vasospasm.<\/jats:p>","DOI":"10.3171\/jns.1988.68.5.0757","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:22:12Z","timestamp":1241799732000},"page":"757-766","source":"Crossref","is-referenced-by-count":35,"title":["Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries"],"prefix":"10.3171","volume":"68","author":[{"given":"Tadayoshi","family":"Nakagomi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal F.","family":"Kassell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomio","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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