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Of these 165 patients, 131 (79.4%) have a GH level less than 5 ng\/ml and 153 (92.7%) have a level below 10 ng\/ml; these represent 75.3% and 87.9%, respectively, of the total 174 patients reviewed. Fifty-two patients received postoperative radiation therapy. Nine patients underwent reoperation. There were five cases of tumor recurrence following an apparent surgical cure (4.3%), nine new instances of anterior pituitary hypofunction (5%), and five failures of multimodality therapy (2.3%). There were no perioperative deaths, five cases of cerebrospinal fluid leak requiring surgical repair (2.2%), and four cases of postoperative meningitis (1.8%). Permanent diabetes insipidus did not occur. Two of 52 patients who were irradiated postoperatively had severe complications; 23 (54.8%) of 42 patients who were available for follow-up evaluation had developed panhypopituitarism; and eight (19%) of 42 had normal pituitary function an average of 44 months postirradiation.<\/jats:p>","DOI":"10.3171\/jns.1988.68.6.0854","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:14:12Z","timestamp":1241799252000},"page":"854-867","source":"Crossref","is-referenced-by-count":178,"title":["Results of transsphenoidal microsurgery for growth hormone-secreting pituitary adenoma in a series of 214 patients"],"prefix":"10.3171","volume":"68","author":[{"given":"Donald A.","family":"Ross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles 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