{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T19:59:14Z","timestamp":1780603154376,"version":"3.54.1"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,10]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Bromodeoxyuridine (BUdR), a nonhypoxic radiosensitizing drug, is a halogenated pyrimidine analog that is incorporated into the deoxyribonucleic acid of dividing cells in a competitive process with thymidine; BUdR also sensitizes these cells to radiation therapy. Neurons and glial cells have a very low mitotic rate. They will not incorporate BUdR and will not be sensitized. Bromodeoxyuridine is best delivered intra-arterially because of its regional advantage, calculated to be between 6 and 16. An 8-week BUdR infusion is delivered before and during radiation therapy through a permanently implanted pump with a catheter placed retrograde into the external carotid artery. Eighteen patients with malignant glioma (15 grade IV, and three grade III) were entered into a Phase I dose-escalation protocol with BUdR dosages ranging from 400 to 600 mg\/sq m\/day. The maximum dose that can be tolerated appears to be 400 mg\/sq m\/day for 8 weeks. The 18 patients entered in this study have a median Kaplan-Meier estimated survival time (\u00b1 standard error of the mean) of 22 \u00b1 5 months with 11 patients still alive. Three patients are alive at 30, 29, and 21 months after diagnosis with no evidence of tumor on computerized tomography. There have been no vascular complications. Side effects in all patients have included anorexia, fatigue, ipsilateral forehead dermatitis, blepharitis, iritis, and nail ridging. Myelosuppression requiring dose reduction occurred in one patient. One patient had a Stevens-Johnson syndrome requiring termination of BUdR. It is concluded that intra-arterial BUdR may improve survival times in patients with malignant gliomas.<\/jats:p>","DOI":"10.3171\/jns.1988.69.4.0500","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:15:30Z","timestamp":1241799330000},"page":"500-505","source":"Crossref","is-referenced-by-count":30,"title":["Intra-arterial bromodeoxyuridine radiosensitization and radiation in treatment of malignant astrocytomas"],"prefix":"10.3171","volume":"69","author":[{"given":"Harry S.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard F.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Ensminger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Junck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaelyn A.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen S.","family":"Gebarski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"McKeever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry W.","family":"Hood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Stetson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen S.","family":"Litchter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Tankanow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.2214\/ajr.99.4.886","volume":"99","author":"Bagshaw MA","year":"1967","journal-title":"AJR"},{"key":"b2","first-page":"75","volume":"47","author":"Brown JM","year":"1971","journal-title":"JNCI"},{"key":"b3","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1084\/jem.112.3.509","volume":"112","author":"Djordjevic B","year":"1960","journal-title":"J Exp Med"},{"key":"b4","first-page":"107","volume-title":"Modern Trends in Radiotherapy.","author":"Doggett RLS","year":"1967"},{"key":"b5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/BF01059765","volume":"2","author":"Eckman WW","year":"1974","journal-title":"J Pharmacokinet Biopharmaceut"},{"key":"b6","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/0006-291X(61)90229-7","volume":"4","author":"Erikson RL","year":"1961","journal-title":"Biochem Biophys Res Commun"},{"key":"b7","author":"Greenberg HS","journal-title":"J Neurooncol"},{"key":"b8","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1099\/00221287-22-3-618","volume":"22","author":"Greer S","year":"1960","journal-title":"J Gen Microbiol"},{"key":"b9","first-page":"170","volume-title":"Modern Radiotherapy and Oncology \u2014 Central Nervous System Tumours.","author":"Hoshino T","year":"1974"},{"key":"b10","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1200\/JCO.1984.2.10.1144","volume":"2","author":"Kinsella TJ","year":"1984","journal-title":"J Clin Oncol"},{"key":"b11","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0360-3016(84)90414-0","volume":"10","author":"Kinsella TJ","year":"1984","journal-title":"Int Radiat Oncol Biol Phys"},{"key":"b12","first-page":"260","volume":"23","author":"Kriss JP","year":"1963","journal-title":"Cancer Res"},{"key":"b13","first-page":"254","volume":"22","author":"Kriss JP","year":"1962","journal-title":"Cancer Res"},{"key":"b14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0014-4827(63)90325-2","volume":"30","author":"Mohler WC","year":"1963","journal-title":"Exp Cell Res"},{"key":"b15","author":"National Cancer Institute, Investigational Drug Branch:","year":"1980","journal-title":"Clinical Brochure. 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