{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T21:54:15Z","timestamp":1715550855628},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The ability of antithrombin III, an endogenous plasma glycoprotein, to reverse the arterial narrowing in a rabbit model of cerebral vasospasm was evaluated. The vasodilator activity of antithrombin III on rabbit arteries was first assessed <jats:italic>in vitro<\/jats:italic> using a myograph-arterial ring preparation. Antithrombin III (10 IU\/ml) induced a 55.4% \u00b1 2.66% (mean \u00b1 standard error of the mean) relaxation in basilar artery precontracted with serotonin (5-HT) in five specimens as compared with a 9.8% \u00b1 1.6% relaxation of common carotid artery in six specimens. For <jats:italic>in vivo<\/jats:italic> analysis, 21 New Zealand White male rabbits were separated into three groups: Group 1 served as normal controls; Group 2 received a subarachnoid blood injection (SAH) and were sacrificed on Day 3 thereafter; and Group 3 animals were subjected to SAH, then received a 2-hour intracisternal infusion of antithrombin III (100 IU) in saline prior to sacrifice on Day 3. Basilar artery caliber was determined using a morphometric method to analyze perfusion-fixed arterial segments. Control basilar artery diameter in Group 1 was 0.64 \u00b1 0.02 mm. In Group 2 a 27% reduction in arterial caliber to 0.47 \u00b1 0.03 mm was observed by Day 3 post SAH (p &lt; 0.0001). Group 3 animals had a mean basilar artery diameter of 0.68 \u00b1 0.02 mm. This was significantly larger than the untreated SAH rabbits in Group 2 (p &lt; 0.0001), but not different from control artery diameters in Group 1. The findings demonstrate that antithrombin III in saline has a significant ability to reverse delayed narrowing of the rabbit basilar artery after SAH.<\/jats:p>","DOI":"10.3171\/jns.1989.70.4.0599","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:14:21Z","timestamp":1241799261000},"page":"599-604","source":"Crossref","is-referenced-by-count":16,"title":["Effect of intracisternal antithrombin III on subarachnoid hemorrhage-induced arterial narrowing"],"prefix":"10.3171","volume":"70","author":[{"given":"Dennis G.","family":"Vollmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neal F.","family":"Kassell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisayuki","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Tsukahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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