{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:35:45Z","timestamp":1772915745566,"version":"3.50.1"},"reference-count":32,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Two cases of hypothalamic hamartoma are presented. The first patient was a 4-year-old boy with precocious puberty, and the second was a 6-year-old boy with epileptic seizures. In both patients, clinical symptoms and signs appeared at the age of 2 years and progressed thereafter. Computerized tomography and magnetic resonance imaging in both cases disclosed a suprasellar mass lesion in continuity with the hypothalamus. Removal of the lesions affected the endocrinological status and\/or seizure control. Pathological examination revealed the lesions to be composed of well-differentiated neuronal and glial cells. Immunohistochemical study demonstrated the presence of beta-endorphin, corticotropin-releasing factor, oxytocin, and neurofilament protein (210 kD) in the neuronal cells of the first patient, but no neuropeptides were detected in the second. Electron microscopic examination on the second patient disclosed the presence of many nonmyelinated and some myelinated neuronal processes containing dense-core and clear vesicles. The morphological characteristics and the role of surgery for this lesion are discussed.<\/jats:p>","DOI":"10.3171\/jns.1989.70.4.0640","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:14:21Z","timestamp":1241799261000},"page":"640-645","source":"Crossref","is-referenced-by-count":64,"title":["Hypothalamic hamartoma"],"prefix":"10.3171","volume":"70","author":[{"given":"Shunji","family":"Nishio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Aiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwao","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masashi","family":"Fukui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Verh Dtsch Ges Pathol","first-page":"153","article-title":"Ueber Hamartome.","volume":"7","author":"Albrecht","year":"1904"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"583","DOI":"10.3171\/jns.1983.58.4.0583","article-title":"Precocious puberty and hypothalamic hamartoma with total recovery after surgical treatment. 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Case report.","volume":"62","author":"Kyuma","year":"1985"},{"key":"b14","series-title":"Arch Fr Pediatr","first-page":"293","article-title":"Hepato-renal polycystic disease. Apropos of a case associating hepatic cysts, renal cysts and hamartoma of the 3rd ventricle.","volume":"18","author":"Lamy","year":"1961"},{"key":"b15","series-title":"Pathology of the Nervous System.","first-page":"1897","article-title":"Hamartomas and phacomatoses","volume":"2","author":"Lichtenstein","year":"1971"},{"key":"b16","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1007\/BF00395190","article-title":"Neuroradiologic study of hamartomas of the tuber cinereum and hypothalamus.","volume":"16","author":"Lin","year":"1978"},{"key":"b17","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1212\/WNL.8.3.164","article-title":"Posterior hypothalamic hamartomas and gangliogliomas causing precocious puberty.","volume":"8","author":"List","year":"1958"},{"key":"b18","series-title":"J Comput Tomogr","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/0149-936X(86)90017-2","article-title":"Neuroradiologic findings of hypothalamic hamartoma with emphasis on computed tomography.","volume":"10","author":"Nakagawa","year":"1986"},{"key":"b19","series-title":"Neurol Med Chir","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2176\/nmc.27.105","article-title":"Immunoreactivity with \u201chypothalamic\u201d neuropeptides in neuronal neoplasms of the central nervous system. 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