{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T23:44:26Z","timestamp":1768347866144,"version":"3.49.0"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,5]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Spinal cord ischemia may accompany surgical procedures on the aorta or vertebral column. Regional spinal cord blood flow (SCBF) was measured at five vertebral levels in the spinal cords of pentobarbital-anesthetized rats based on the distribution of intravenously injected carbon-14-labeled butanol. In seven normal rats, mean SCBF (\u00b1 standard error of the mean) ranged from 52.7 \u00b1 5.4 to 68.5 \u00b1 4.9 ml \u22c5 min<jats:sup>\u22121<\/jats:sup> \u22c5 100 gm<jats:sup>\u22121<\/jats:sup> (depending on the level, being lowest at the thoracic levels) and mean arterial blood pressure (MABP) was 126 mm Hg. Corporal hypothermia (mean rectal temperature 28.1\u00b0 \u00b1 0.6\u00b0C) was induced by cold exposure in seven other rats, and SCBF, measured immediately thereafter, was significantly elevated at all five levels by 52% to 69% compared to the normal group. However, MABP was elevated in the hypothermic group to 165 \u00b1 4 mm Hg (p &lt; 0.0001). Therefore, in seven additional hypothermic rats, MABP was maintained at the control level by withdrawal of arterial blood as necessary. In these animals, SCBF at all levels was still significantly elevated compared with the normal group and the values were nearly identical to those measured in the hypertensive hypothermic rats. It was concluded that hemodynamic autoregulation of SCBF is impaired in the presence of moderate systemic hypothermia in pentobarbital-anesthetized rats.<\/jats:p>","DOI":"10.3171\/jns.1989.70.5.0780","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:17:13Z","timestamp":1241799433000},"page":"780-784","source":"Crossref","is-referenced-by-count":12,"title":["The effect of hypothermia on regional spinal cord blood flow in rats"],"prefix":"10.3171","volume":"70","author":[{"given":"Toshihisa","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William W.","family":"Monafo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Circulation","first-page":"112","article-title":"Mechanisms of spinal cord injury after cross-clamping of the descending thoracic aorta.","volume":"66","author":"Berendes","year":"1982"},{"key":"b2","series-title":"Ann Thorac Surg","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/S0003-4975(10)60238-X","article-title":"Hypothermic regional perfusion for protection of the spinal cord during periods of ischemia.","volume":"43","author":"Colon","year":"1987"},{"key":"b3","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1136\/jnnp.36.6.914","article-title":"Spinal cord blood flow in dogs: the effect of blood pressure.","volume":"36","author":"Griffiths","year":"1973"},{"key":"b4","series-title":"Can J Neurol Sci","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1017\/S0317167100046758","article-title":"The effects of local cooling on canine spinal cord blood flow.","volume":"12","author":"Hansebout","year":"1985"},{"key":"b5","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1161\/01.STR.17.6.1183","article-title":"Autoregulation of spinal cord blood flow: is the cord a microcosm of the brain?","volume":"17","author":"Hickey","year":"1986"},{"key":"b6","series-title":"J Appl Physiol","doi-asserted-by":"publisher","first-page":"1484","DOI":"10.1152\/jappl.1966.21.5.1484","article-title":"Nomograms for correction of blood pO2, pCO2, pH, and base excess for time and temperature.","volume":"21","author":"Kelman","year":"1966"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"12","DOI":"10.3171\/jns.1976.44.1.0012","article-title":"Spinal cord flow as affected by changes in systemic arterial blood pressure.","volume":"44","author":"Kobrine","year":"1976"},{"key":"b8","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1161\/01.RES.41.1.128","article-title":"Regulation of total and regional spinal cord blood flow.","volume":"41","author":"Marcus","year":"1977"},{"key":"b9","series-title":"Anesthesiology","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1097\/00000542-196811000-00005","article-title":"Hypothermia: effect on canine brain and whole-body metabolism.","volume":"29","author":"Michenfelder","year":"1968"},{"key":"b10","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1080\/01616412.1983.11739634","article-title":"Regional spinal cord and brain blood flows in the rat.","volume":"5","author":"Nystr\u00f6m","year":"1983"},{"key":"b11","series-title":"J Neurosurg","first-page":"5","article-title":"The pathophysiological response to spinal cord injury. 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