{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:19:50Z","timestamp":1761823190810},"reference-count":70,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The purpose of this study was to use a new 21-aminosteroid (U-74006F) with <jats:italic>in vitro<\/jats:italic> antioxidant and antilipolytic properties as a pharmacological probe to assess the role of lipid hydrolysis and peroxidation in a rabbit model of subarachnoid hemorrhage (SAH)-induced vasospasm. Cerebral angiograms were performed on 15 rabbits. Eighteen hours later, 1 cc\/kg of autologous blood was infused into the cisterna magna of all 15 animals. Six rabbits received no treatment, six received U-74006F starting 30 minutes after SAH, and three rabbits received the vehicle for U-74006F starting 30 minutes after SAH. At 72 hours post-SAH, a second angiogram was obtained. Digital subtraction angiographic techniques were used to measure the diameter of and contrast material flow through the basilar artery. At 72 hours post-SAH, vasospasm was evident in all untreated and vehicle-treated rabbits. The diameter of and the flow through the basilar artery were significantly reduced 42.3% \u00b1 6.6% and 46.8% \u00b1 5.8%, respectively, below pre-SAH levels (means \u00b1 standard error of the means). Treatment with U-74006F eliminated the SAH-induced vasospasm; in treated animals, both the flow through and the diameter of the basilar arteries were at pre-SAH levels. These findings indicate that: 1) membrane lipid changes (that is, hydrolysis with eicosanoid production and\/or peroxidation) contribute to the chronic vasospasm resulting from SAH, and 2) U-74006F prevents the SAH-induced chronic vasospasm in this model by limiting these pathological membrane events.<\/jats:p>","DOI":"10.3171\/jns.1989.71.1.0098","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:21:09Z","timestamp":1241799669000},"page":"98-104","source":"Crossref","is-referenced-by-count":99,"title":["Effect of the 21-aminosteroid U-74006F on cerebral vasospasm following subarachnoid hemorrhage"],"prefix":"10.3171","volume":"71","author":[{"given":"Mario","family":"Zuccarello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery T.","family":"Marsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Woodward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas K.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Pharmacol Exp Ther","first-page":"347","article-title":"Contractile response of isolated rabbit aortic strips to unsaturated fatty acid peroxides.","volume":"208","author":"Asano","year":"1979"},{"key":"b2","series-title":"Pharmacology","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000137971","article-title":"Contractile responses of mammalian cerebral arteries to 15-hydroperoxyarachidonic acid vary in the presence of fusaric acid and verapamil.","volume":"28","author":"Asano","year":"1984"},{"key":"b3","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1080\/01616412.1984.11739663","article-title":"Experimental evaluation of the beneficial effect of an antioxidant on cerebral vasospasm.","volume":"6","author":"Asano","year":"1984"},{"key":"b4","series-title":"Cerebral Arterial Spasm.","first-page":"190","article-title":"Possible participation of free radical reactions initiated by clot lysis in the pathogenesis of vasospasm after subarachnoid hemorrhage","author":"Asano","year":"1980"},{"key":"b5","series-title":"Biochem Cell Biol","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1139\/o87-057","article-title":"The release of radioactive arachidonate from lipids of red blood cells during prolonged incubations in vitro.","volume":"65","author":"Baker","year":"1987"},{"key":"b6","series-title":"J Biol Chem","doi-asserted-by":"publisher","first-page":"7816","DOI":"10.1016\/S0021-9258(19)57008-9","article-title":"Transformation of arachidonic acid and homo-\u03b3-linolenic acid by rabbit polymorphonuclear leukocytes.","volume":"251","author":"Borgeat","year":"1976"},{"key":"b7","series-title":"Proc Natl Acad Sci USA","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1073\/pnas.76.5.2148","article-title":"Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187.","volume":"76","author":"Borgeat","year":"1979"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3171\/jns.1983.59.2.0231","article-title":"The role of hemoglobin in the etiology of cerebral vasospasm. 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