{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T14:51:38Z","timestamp":1769007098607,"version":"3.49.0"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Idiopathic giant-cell granulomatous hypophysitis is a chronic inflammatory disorder of the pituitary gland. It presents clinically as a sellar mass lesion with pituitary insufficiency and\/or hyperprolactinemia, and is radiologically indistinguishable from a pituitary tumor. In most of the previously reported cases the documentation of the disorder has been limited to autopsy tissue. Only a few cases documented by biopsy have been recorded. Four cases are presented here with radiological, endocrinological, and surgical findings. The appropriately documented cases collected from the literature and the present series are reviewed and the incidence, patterns of clinical and radiological presentation, and operative management of this disorder are discussed. This entity should be considered when evaluating patients with a pituitary mass and evidence of hypopituitarism and hyperprolactinemia.<\/jats:p>","DOI":"10.3171\/jns.1989.71.5.0681","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T16:18:16Z","timestamp":1241799496000},"page":"681-686","source":"Crossref","is-referenced-by-count":52,"title":["Giant-cell granulomatous hypophysitis: a distinct clinicopathological entity"],"prefix":"10.3171","volume":"71","author":[{"given":"Massimo","family":"Scanarini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"d'Avella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Rotilio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolaos","family":"Kitromilis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Mingrino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1227\/00006123-198801010-00022","article-title":"Triad of hypopituitarism, granulomatous hypophysitis, and ruptured Rathke's cleft cyst.","volume":"22","author":"Albini","year":"1988"},{"key":"b2","series-title":"Arch Intern Med","doi-asserted-by":"publisher","first-page":"877","DOI":"10.1001\/archinte.1952.00240060020003","article-title":"Sarcoid-like granulomata of the pituitary gland. A cause of pituitary insufficiency.","volume":"89","author":"Bleish","year":"1952"},{"key":"b3","series-title":"Neurosurgery","first-page":"723","article-title":"Comment on Esposito V, Fraioli B, Ferrante L, et al: Intrasellar tuberculoma: case report.","volume":"21","author":"Ciric","year":"1987"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"814","DOI":"10.3171\/jns.1979.50.6.0814","article-title":"Neurosarcoidosis with computerized tomographic visualization and transsphenoidal excision of supra- and intrasellar granuloma. Case report.","volume":"50","author":"Decker","year":"1979"},{"key":"b5","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3171\/jns.1980.53.5.0717","article-title":"Intrasellar granuloma. Case report.","volume":"53","author":"Del Pozo","year":"1980"},{"key":"b6","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1227\/00006123-198711000-00021","article-title":"Intrasellar tuberculoma: case report.","volume":"21","author":"Esposito","year":"1987"},{"key":"b7","series-title":"Arch Pathol","first-page":"631","article-title":"Gumma of the hypophysis and hypothalamus.","volume":"15","author":"Fink","year":"1933"},{"key":"b8","series-title":"Nouv Iconog Salpetriere","first-page":"449","article-title":"Insuffisance pluriglandulaire interne thyrotesticulo-surrenale.","volume":"24","author":"Gougerot","year":"1911"},{"key":"b9","series-title":"Acta Neuropathol","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/BF00691994","article-title":"Prolactinoma coexistent with granulomatous hypophysitis.","volume":"61","author":"Holck","year":"1983"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3171\/jns.1981.55.2.0194","article-title":"Serum prolactin in patients with hypothalamus and pituitary disorders.","volume":"55","author":"Lundberg","year":"1981"},{"key":"b11","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1227\/00006123-198705000-00021","article-title":"Lymphocytic adenohypophysitis of pregnancy with complete recovery.","volume":"20","author":"McGrail","year":"1987"},{"key":"b12","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1227\/00006123-198711000-00020","article-title":"Isolated histiocytosis X of the pituitary gland: case report.","volume":"21","author":"Nishio","year":"1987"},{"key":"b13","series-title":"Pathologica","first-page":"247","article-title":"Granuloma a cellule giganti dell'ipofisi.","volume":"76","author":"Novaro","year":"1984"},{"key":"b14","series-title":"Q J Med","first-page":"425","article-title":"Giant cell granulomas and other pituitary granulomata.","volume":"23","author":"Rickards","year":"1954"},{"key":"b15","series-title":"Q J Med","first-page":"319","article-title":"The syndrome of hypopituitarism.","volume":"18","author":"Sheehan","year":"1949"},{"key":"b16","series-title":"Virchows Arch Pathol Anat","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/BF02034323","article-title":"\u00dcber das Vorkommen von Riesenzellen in der Hypophyse.","volume":"223","author":"Simmonds","year":"1917"},{"key":"b17","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"584","DOI":"10.3171\/jns.1980.52.4.0584","article-title":"Giant cell granuloma involving the pituitary gland. Case report.","volume":"52","author":"Taylon","year":"1980"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/71\/5\/article-p681.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/71\/5\/article-p681.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/71\/5\/article-p681.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T21:32:57Z","timestamp":1679866377000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/71\/5\/article-p681.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":17,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1989.71.5.0681","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}