{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:35:55Z","timestamp":1771068955574,"version":"3.50.1"},"reference-count":20,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Between 1972 and 1988, 25 patients were treated by radiation therapy (RT) alone for pituitary macroadenomas causing visual impairment. Twenty-three patients were evaluated by a neuro-ophthalmologist before treatment and at the time of follow-up review. Radiation treatment consisted of 4000 to 5000 cGy over 4 to 5 weeks. The median follow-up period was 36 months (range 2 to 192 months). Eighteen patients (78%) experienced visual field improvement. Deterioration occurred in four patients due to tumor recurrence, tumor hemorrhage, possible optic nerve necrosis, and optic chiasm herniation. Visual field improvement occurred predominantly in patients whose pretreatment visual field defects were less than a dense hemianopsia, who did not have diffuse optic atrophy, and who were younger than the median age of 69 years (p &lt; 0.001). Visual acuity improvement occurred in patients without diffuse optic atrophy, with only mild impairment of the visual acuity, and with only mild visual field loss prior to RT (p &lt; 0.002). It is concluded that there is a subset of patients with pituitary macroadenomas and visual impairment for whom primary RT is a treatment option.<\/jats:p>","DOI":"10.3171\/jns.1990.72.4.0594","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:19:39Z","timestamp":1242238779000},"page":"594-599","source":"Crossref","is-referenced-by-count":18,"title":["Neuro-ophthalmological assessment of vision before and after radiation therapy alone for pituitary macroadenomas"],"prefix":"10.3171","volume":"72","author":[{"given":"Stephen C.","family":"Rush","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Kupersmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irving","family":"Lerch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Ransohoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Newall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/0360-3016(77)90046-3","article-title":"The relationship of time-dose fractionation factors to complications in the treatment of pituitary tumors by irradiation.","volume":"2","author":"Aristizabal","year":"1977"},{"key":"b2","series-title":"Radiation Therapy of Tumors and Diseases of the Nervous System.","author":"Bouchard","year":"1966"},{"key":"b3","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1148\/98.3.655","article-title":"Cobalt-60 teletherapy of pituitary adenomas.","volume":"98","author":"Carlson","year":"1971"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"395","DOI":"10.3171\/jns.1983.59.3.0395","article-title":"Transsphenoidal microsurgery of pituitary macroadenomas with long-term follow-up results.","volume":"59","author":"Ciric","year":"1983"},{"key":"b5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1227\/00006123-198509000-00008","article-title":"Visual recovery after transsphenoidal removal of pituitary adenomas.","volume":"17","author":"Cohen","year":"1985"},{"key":"b6","series-title":"BMDP Statistical Software.","first-page":"93","year":"1985"},{"key":"b7","series-title":"Pathology of Radiation Injury.","first-page":"252","article-title":"Pathogenesis of radiation injury","author":"Fajardo","year":"1982"},{"key":"b8","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1148\/120.1.167","article-title":"Visual complications following irradiation for pituitary adenomas and craniopharyngiomas.","volume":"120","author":"Harris","year":"1976"},{"key":"b9","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1093\/neurosurgery\/15.CN_suppl_1.301","article-title":"The hazards of therapeutic irradiation of the central nervous system.","volume":"15","author":"Kramer","year":"1968"},{"key":"b10","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3171\/jns.1977.46.6.0717","article-title":"Transsphenoidal decompression of the optic nerve and chiasm. 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Report of two cases.","volume":"24","author":"Waltz","year":"1966"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/72\/4\/article-p594.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/72\/4\/article-p594.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/72\/4\/article-p594.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T22:02:30Z","timestamp":1679868150000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/72\/4\/article-p594.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":20,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/jns.1990.72.4.0594","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}