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Intrathecal administration of the substance P antagonist spantide 2 hours prior to SAH also prevents the development of vasospasm, while spantide administration 1 hour before SAH only hinders the occurrence of late vasospasm. Intracisternal administration of spantide 2 hours post-SAH prevents the development of late vasospasm. This antagonist <jats:italic>per se<\/jats:italic> can induce a short-lasting dose-dependent angiographic vasoconstriction. Substance P-containing nerve fibers on the cerebral arteries could constitute the sensory link in a reflex arc system involved in the development of vasospasm in which the presence of blood in the subarachnoid space stimulates sensory substance P-containing nerve fibers on the cerebral arteries inducing a centripetal impulse to the A<jats:sub>2<\/jats:sub>-nucleus tractus solitarius and setting into motion the events in the brain stem leading to acute and late vasospasm.<\/jats:p>","DOI":"10.3171\/jns.1990.72.6.0917","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:20:32Z","timestamp":1242238832000},"page":"917-925","source":"Crossref","is-referenced-by-count":18,"title":["Prevention of cerebral vasospasm in the rat by depletion or inhibition of substance P in conducting vessels"],"prefix":"10.3171","volume":"72","author":[{"given":"Tia Juana","family":"Delgado-Zygmunt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed Abdul-Rahman","family":"Arbab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Edvinsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Aage","family":"Svendgaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Acta Physiol Scand","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1111\/j.1748-1716.1982.tb07036.x","article-title":"Intrathecal (D-Pro2, D-Trp7,9)-SP elicits hypoalgesia and motor blockade in the rat and antagonizes noxious responses induced by substance P.","volume":"114","author":"\u00c5kerman","year":"1982"},{"key":"b2","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1056\/NEJM198303173081103","article-title":"Cerebral arterial spasm \u2014 a controlled trial of nimodipine in patients with subarachnoid hemorrhage.","volume":"308","author":"Allen","year":"1983"},{"key":"b3","series-title":"J Cereb Blood Flow Metab","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1038\/jcbfm.1988.8","article-title":"Brain stem terminations of the trigeminal and upper spinal ganglia innervation of the cerebrovascular system: WGA-HRP transganglionic study.","volume":"8","author":"Arbab","year":"1988"},{"key":"b4","series-title":"Neuroscience","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1016\/0306-4522(86)90293-9","article-title":"Origin and distribution of cerebral vascular innervation from superior cervical, trigeminal and spinal ganglia investigated with retrograde and anterograde WGA-HRP tracing in the rat.","volume":"19","author":"Arbab","year":"1986"},{"key":"b5","series-title":"Br J Pharmacol","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1476-5381.1984.tb10084.x","article-title":"Neonatal capsaicin treatment impairs vasopressin-mediated blood pressure recovery following acute hypotension.","volume":"81","author":"Bennett","year":"1984"},{"key":"b6","series-title":"Pharmacol Rev","first-page":"179","article-title":"The neuropharmacology of capsaicin: review of some recent observations.","volume":"38","author":"Buck","year":"1986"},{"key":"b7","series-title":"Arch Neurol Psychiatry","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1001\/archneurpsyc.1936.02260050128008","article-title":"Experimental studies on headache. 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