{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T05:26:39Z","timestamp":1773120399433,"version":"3.50.1"},"reference-count":64,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The effects of a platelet-activating factor (PAF) antagonist on brain edema, cortical microcirculation, blood-brain barrier (BBB) disruption, and neuronal death following focal brain injury are reported. A neodymium:yttrium-aluminum-garnet (Nd:YAG) laser was used to induce highly reproducible focal cortical lesions in anesthetized rats. Secondary brain damage in this model was characterized by progressive cortical hypoperfusion, edema, and BBB disruption in the vicinity of the hemispheroid lesion occurring acutely after injury. The histopathological evolution was followed for up to 4 days. Neuronal damage in the cortex and the hippocampus (CA-1) was assessed quantitatively, revealing secondary and progressive loss of neuronal tissue within the first 24 hours following injury.<\/jats:p>\n<jats:p content-type=\"fine-print\">Pretreatment with the PAF antagonist BN 50739 ameliorated the severe hypoperfusion in 12 rats (increasing local cerebral blood flow from a mean \u00b1 standard error of the mean of 40.5% \u00b1 8.3% to 80.2% \u00b1 7.8%, p &lt; 0.01) and reduced edema by 70% in 10 rats (p &lt; 0.05) acutely after injury. The PAF antagonist also reduced the progression of neuronal damage in the cortex and the CA-1 hippocampal neurons (decrease of neuronal death from 88.0% \u00b1 3.9% to 49.8% \u00b1 4.2% at 24 hours in the cortex and from 40.2 \u00b1 5.0% to 13.2% \u00b1 2.1% in the hippocampus in 30 rats; p &lt; 0.05).<\/jats:p>\n<jats:p content-type=\"fine-print\">This study provides evidence to support progressive brain damage following focal brain injury, associated with secondary loss of neuronal cells. In this latter process, PAF antagonists may provide significant therapeutic protection in arresting secondary brain damage following cerebral ischemia and neurological trauma.<\/jats:p>","DOI":"10.3171\/jns.1990.73.2.0223","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:18:52Z","timestamp":1242238732000},"page":"223-233","source":"Crossref","is-referenced-by-count":62,"title":["Platelet-activating factor and progressive brain damage following focal brain injury"],"prefix":"10.3171","volume":"73","author":[{"given":"Kai U.","family":"Frerichs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perttu J.","family":"Lindsberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M.","family":"Hallenbeck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giora Z.","family":"Feuerstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1227\/00006123-198902000-00003","article-title":"Intraoperative measurement of cerebral and tumor blood flow with laser-Doppler flowmetry.","volume":"24","author":"Arbit","year":"1989"},{"key":"b2","series-title":"Circ Res","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.RES.62.1.1","article-title":"Platelet activating factor: a potent constrictor of cerebral arterioles in newborn pigs.","volume":"62","author":"Armstead","year":"1988"},{"key":"b3","series-title":"Crit Care Med","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1097\/00003246-198810000-00008","article-title":"Mediators of brain edema and secondary brain damage.","volume":"16","author":"Baethmann","year":"1988"},{"key":"b4","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3171\/jns.1989.70.4.0578","article-title":"Release of glutamate and of free fatty acids in vasogenic brain edema.","volume":"70","author":"Baethmann","year":"1989"},{"key":"b5","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1007\/BF01650032","article-title":"The use of the Nd-YAG and the CO2 laser in neurosurgery.","volume":"3","author":"Beck","year":"1980"},{"key":"b6","series-title":"Neurosurg Rev","first-page":"31","article-title":"Tissue changes following application of lasers to the rabbit brain. 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