{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:49:35Z","timestamp":1787104175255,"version":"build-2736575974"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,9]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The congenital osseous abnormalities associated with achondroplasia include stenosis of the foramen magnum and the upper cervical spinal canal. In the pediatric achondroplastic patient, such stenosis may lead to cervicomedullary compression with serious sequelae, including paresis, hypertonia, delayed motor milestones, and respiratory compromise. Using a standardized protocol the authors have treated 15 young achondroplastic patients with documented cervicomedullary compression by craniocervical decompression and duroplasty. Following this procedure, significant improvement in presenting neurological or respiratory complaints was noted in all patients. The mortality rate in this series was zero. The major cause of morbidity associated with this procedure was perioperative cerebrospinal fluid (CSF) leakage from the surgical wound, presumably related to coexisting abnormalities of CSF dynamics. This problem was successfully managed by temporary or, when necessary, permanent CSF diversion procedures. It is concluded that craniocervical decompression is an effective and safe treatment for young achondroplastic patients with cervicomedullary compression.<\/jats:p>","DOI":"10.3171\/jns.1990.73.3.0375","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:19:14Z","timestamp":1242238754000},"page":"375-382","source":"Crossref","is-referenced-by-count":64,"title":["Craniocervical decompression for cervicomedullary compression in pediatric patients with achondroplasia"],"prefix":"10.3171","volume":"73","author":[{"given":"John","family":"Aryanpur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orest","family":"Hurko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clair","family":"Francomano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Carson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Dev Med Child Neurol","first-page":"489","article-title":"Unexpected death of children with achondroplasia after the perinatal period.","volume":"24","author":"Bland","year":"1982"},{"key":"b2","series-title":"Human Achondroplasia.","first-page":"207","article-title":"Surgical management of cervico-medullary compression in achondroplastic patients","author":"Carson","year":"1988"},{"key":"b3","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/S0022-3476(67)80296-8","article-title":"Neurological abnormalities in achondroplastic children.","volume":"71","author":"Cohen","year":"1967"},{"key":"b4","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1212\/WNL.12.3.202","article-title":"Compressive spinal cord and root syndromes in achondroplastic dwarfs.","volume":"12","author":"Duvoisin","year":"1962"},{"key":"b5","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1212\/WNL.5.12.875","article-title":"Compression of spinal cord and cauda equina in achondroplastic dwarfs.","volume":"5","author":"Epstein","year":"1955"},{"key":"b6","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1016\/S0022-3476(84)81103-8","article-title":"Apnea as the sole manifestation of cord compression in achondroplasia.","volume":"104","author":"Fremion","year":"1984"},{"key":"b7","series-title":"Eur J Pediatr","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1007\/BF00442750","article-title":"Long-term neurological sequelae in achondroplasia.","volume":"143","author":"Hecht","year":"1984"},{"key":"b8","series-title":"Am J Hum Genet","first-page":"454","article-title":"Mortality in achondroplasia.","volume":"41","author":"Hecht","year":"1987"},{"key":"b9","series-title":"Am J Med Genet","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/ajmg.1320200219","article-title":"Computerized tomography of the foramen magnum: achondroplastic values compared to normal standards.","volume":"20","author":"Hecht","year":"1985"},{"key":"b10","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1097\/00004728-198006000-00006","article-title":"Distinction between obstructive and atrophic dilatation of ventricles in children.","volume":"4","author":"Heinz","year":"1980"},{"key":"b11","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1001\/archneur.1983.04050110087019","article-title":"Achondroplasia associated with obstructive sleep apnea.","volume":"40","author":"Larsen","year":"1983"},{"key":"b12","series-title":"J Bone Joint Surg (Am)","doi-asserted-by":"publisher","first-page":"87","DOI":"10.2106\/00004623-197759010-00016","article-title":"Neurological symptoms in achondroplastic dwarfs \u2014 surgical treatment.","volume":"59","author":"Lutter","year":"1977"},{"key":"b13","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/BF01809153","article-title":"Basilar impression in an achondroplastic dwarf: causative role in tetraparesis.","volume":"41","author":"Luyendijk","year":"1978"},{"key":"b14","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3171\/jns.1989.70.1.0126","article-title":"Foramen magnum decompression in an infant with homozygous achondroplasia. 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