{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T01:35:29Z","timestamp":1769304929222,"version":"3.49.0"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 This study was designed to investigate the hemodynamic characteristics of cavernous angiomas of the brain. Five adult patients with a cavernous angioma underwent local cortical blood flow studies and vascular pressure measurements during surgery for the excision of the cavernous angioma. Clinical presentation included headache in four patients, seizures in four patients, and recurring diplopia in one patient. Magnetic resonance imaging demonstrated the cavernous angiomas in all patients and revealed an associated small hematoma in two. Four patients with a cerebral cavernous angioma were operated on in the supine position and the remaining patient, whose lesion involved the brain stem, was operated on in the sitting position. Mean local cortical blood flow (\u00b1 standard error of the mean) in the cerebral cortex adjacent to the lesion was 60.5 \u00b1 8.3 ml\/100 gm\/min at a mean PaCO<jats:sub>2<\/jats:sub> of 35.0 \u00b1 0.6 torr. Mean CO<jats:sub>2<\/jats:sub> reactivity was 1.1 \u00b1 0.2 ml\/100 gm\/min\/torr. The local cortical blood flow results were similar to established normal control findings. Mean pressure within the lesion in the patients undergoing surgery while supine was 38.2 \u00b1 0.5 mm Hg; a slight decline in cavernous angioma pressure occurred with a drop in mean systemic arterial blood pressure and PaCO<jats:sub>2<\/jats:sub>. Mean pressure in the cavernous angioma in the patient operated on in the sitting position was 7 mm Hg. Jugular compression resulted in a 9-mm Hg rise in cavernous angioma pressure in one supine patient but no change in the patient in the sitting position. Direct microscopic observation revealed slow circulation within the lesions. The hemodynamic features demonstrated in this study indicate that cavernous angiomas are relatively passive vascular anomalies that are unlikely to produce ischemia in adjacent brain. Frank hemorrhage would be expected to be self-limiting because of relatively low driving pressures.<\/jats:p>","DOI":"10.3171\/jns.1990.73.4.0555","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:20:00Z","timestamp":1242238800000},"page":"555-559","source":"Crossref","is-referenced-by-count":77,"title":["Vascular pressures and cortical blood flow in cavernous angioma of the brain"],"prefix":"10.3171","volume":"73","author":[{"given":"John R.","family":"Little","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Issam A.","family":"Awad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyd Y.","family":"Ebrahim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1227\/00006123-198706000-00003","article-title":"Cerebral circulation during arteriovenous malformation operation.","volume":"20","author":"Barnett","year":"1987"},{"key":"b2","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1227\/00006123-198805000-00003","article-title":"Altered cerebral autoregulation and CO2 reactivity after aneurysmal subarachnoid hemorrhage.","volume":"22","author":"Dernbach","year":"1988"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3171\/jns.1972.36.5.0560","article-title":"Direct measurement of mean and pulsatile blood pressure at operation in human intracranial saccular aneurysms.","volume":"36","author":"Ferguson","year":"1972"},{"key":"b4","series-title":"Clin Neurosurg","first-page":"299","article-title":"Hemodynamics of arteriovenous malformations.","volume":"36","author":"Leblanc","year":"1989"},{"key":"b5","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1227\/00006123-198606000-00006","article-title":"Retinal artery pressure and cerebral artery perfusion pressure in cerebrovascular occlusive disease.","volume":"18","author":"Little","year":"1986"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"456","DOI":"10.3171\/jns.1980.53.4.0456","article-title":"Hemodynamic aspects of cerebral arteriovenous malformations.","volume":"53","author":"Nornes","year":"1980"},{"key":"b7","series-title":"Neurochirurgie","first-page":"95","article-title":"Les malformations vasculaires angiographiquement muettes \u00e9vocatrices d'un cavernome: etude clinique de 18 cas.","volume":"35","author":"Orenstin","year":"1989"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3171\/jns.1987.67.4.0518","article-title":"The MRI appearance of cavernous malformations (angiomas).","volume":"67","author":"Rigamonti","year":"1987"},{"key":"b9","series-title":"Neurochirurgie","first-page":"89","article-title":"Imagerie des cavernomes de l'enc\u00e9phale. Tomodensitom\u00e9trie et imagerie par r\u00e9sonance magn\u00e9tique.","volume":"35","author":"Sigal","year":"1989"},{"key":"b10","series-title":"Neurochirurgie","first-page":"84","article-title":"Y a-t-il une relation entre manifestation clinique et l'image pathologique des cavernomes c\u00e9r\u00e9braux?","volume":"35","author":"Steiger","year":"1989"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/73\/4\/article-p555.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/73\/4\/article-p555.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/73\/4\/article-p555.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T01:46:14Z","timestamp":1679276774000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/73\/4\/article-p555.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":10,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/jns.1990.73.4.0555","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}