{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:14:55Z","timestamp":1761894895752},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,10]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Whipple's disease is infrequently considered in the differential diagnosis of patients presenting with progressive neurological deterioration. This is in part a result of the relative rarity of this entity and in part due to the more frequent initial presentation of the disease with gastrointestinal, musculoskeletal, or cardiovascular symptoms. A case is described in which the neurological symptoms of progressive dementia and weakness were seen in the relative absence of non-neurological symptomatology. The diagnosis of Whipple's disease was made from a brain biopsy. The neuropathology of Whipple's disease of the central nervous system is described and the importance of considering it as a treatable entity in the differential diagnosis of progressive neurological deterioration, despite the absence of systemic symptomatology, is stressed.<\/jats:p>","DOI":"10.3171\/jns.1990.73.4.0623","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:20:00Z","timestamp":1242238800000},"page":"623-627","source":"Crossref","is-referenced-by-count":35,"title":["Whipple's disease presenting with isolated neurological symptoms"],"prefix":"10.3171","volume":"73","author":[{"given":"Adam P.","family":"Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy C.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis G.","family":"Vollmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Ann Neurol","first-page":"102","article-title":"Whipple's disease confined to the central nervous system.","volume":"21","author":"Adams","year":"1987"},{"key":"b2","series-title":"Am J Med","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/0002-9343(64)90203-7","article-title":"Bacillus-like bodies in Whipple's disease; disappearance with clinical remission after antibiotic therapy.","volume":"37","author":"Ashworth","year":"1964"},{"key":"b3","series-title":"Am J Gastroenterol","first-page":"107","article-title":"Whipple's disease: a review.","volume":"78","author":"Comer","year":"1983"},{"key":"b4","series-title":"Whipple's Disease.","first-page":"113","author":"Dobbins","year":"1987"},{"key":"b5","series-title":"Gastroenterology","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1016\/0016-5085(81)90259-6","article-title":"Bacillary characteristics in Whipple's disease. 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