{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:18:36Z","timestamp":1780503516558,"version":"3.54.1"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Sixteen children underwent 18 operations for radical resection of chiasmatic-hypothalamic tumors. The clinical presentation correlated with age: infants under 1 year of age presented with macrocephaly, failure to thrive, and severe visual failure; children aged 1 to 5 years predominantly had precocious puberty with mild visual deficits; and older children (&gt; 5 years old) had slowly progressive loss of vision. All three infants had biologically aggressive tumors in spite of low-grade histology, and died from progressive tumor growth. Eleven of the 13 children aged 1 year or over are alive and well, without clinical or radiographic evidence of disease progression, 4 months to 4\u00bd years following surgery. Six of these patients, with a follow-up period of 10 months to 4\u00bd years (mean 27 months), have had no adjuvant therapy following radical surgical resection. The authors conclude that: 1) radical surgical resection of chiasmatic-hypothalamic tumors can be performed with minimal morbidity; 2) radical resection may delay the time to disease progression in older children and postpone the need for irradiation; 3) resection of postirradiation recurrent tumors may provide neurological improvement and long-lasting clinical remission; and 4) chiasmatic-hypothalamic tumors of infancy are aggressive neoplasms that require multimodality therapy.<\/jats:p>","DOI":"10.3171\/jns.1990.73.5.0661","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:15:09Z","timestamp":1242238509000},"page":"661-667","source":"Crossref","is-referenced-by-count":131,"title":["Surgical management of exophytic chiasmatic-hypothalamic tumors of childhood"],"prefix":"10.3171","volume":"73","author":[{"given":"Jeffrey H.","family":"Wisoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Abbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Epstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"138","DOI":"10.3171\/jns.1985.63.1.0138","article-title":"Cavitron ultrasonic surgical aspirator and visual evoked potential monitoring for chiasmal gliomas in children. 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