{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:13:51Z","timestamp":1790813631890,"version":"4.1.0"},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 To explore the potential usefulness of imaging studies in the diagnosis of focal central nervous system (CNS) lesions associated with acquired immunodeficiency syndrome (AIDS), the authors retrospectively examined the radiographic studies of 149 AIDS patients who presented with signs and symptoms of the three most common focal CNS lesions. Of these patients, 74 (50%) had <jats:italic>Toxoplasma<\/jats:italic> abscesses, 45 (30%) had primary CNS lymphoma, and 30 patients (20%) had progressive multifocal leukoencephalopathy (PML). Magnetic resonance (MR) imaging was more sensitive than computerized tomography (CT) in detecting lesions, especially in cases of PML. Whereas CT was unable to distinguish mass lesions caused by toxoplasmosis from those caused by lymphoma, 71% of the solitary lesions seen on MR images were lymphomas. These results indicate that empirical treatment for toxoplasmosis, the most common initial treatment for AIDS patients with neurological symptoms stemming from mass lesions, is not likely to be successful for patients with solitary lesions on MR images. Rather, early biopsy is advisable. If the presence of lymphoma is confirmed, the rapid initiation of treatment can allow prolonged high-quality survival.<\/jats:p>","DOI":"10.3171\/jns.1990.73.5.0720","type":"journal-article","created":{"date-parts":[[2009,5,13]],"date-time":"2009-05-13T18:15:09Z","timestamp":1242238509000},"page":"720-724","source":"Crossref","is-referenced-by-count":148,"title":["Use of CT and MR imaging to distinguish intracranial lesions and to define the need for biopsy in AIDS patients"],"prefix":"10.3171","volume":"73","author":[{"given":"Samuel F.","family":"Ciricillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Rosenblum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"AIDS and the Nervous System.","first-page":"121","article-title":"Neuroradiology of acquired immunodeficiency syndrome","author":"De La Paz","year":"1988"},{"key":"b2","series-title":"Am J Phys Imag","first-page":"124","article-title":"A comparison of imaging, clinical, and pathological aspects of space-occupying lesions within the brain in patients with acquired immune deficiency syndrome.","volume":"1","author":"Gill","year":"1986"},{"key":"b3","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1097\/00004728-198809010-00013","article-title":"MR imaging of lymphomas: impact on therapy.","volume":"12","author":"Greco","year":"1988"},{"key":"b4","series-title":"AJR","doi-asserted-by":"publisher","first-page":"271","DOI":"10.2214\/ajr.146.2.271","article-title":"Radiographical findings in 32 cases of primary CNS lymphoma.","volume":"146","author":"Jack","year":"1986"},{"key":"b5","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1001\/archneur.1988.00520310037014","article-title":"Acquired immunodeficiency syndrome, magnetic resonance patterns of brain involvement with pathologic correlation.","volume":"45","author":"Jarvik","year":"1988"},{"key":"b6","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"475","DOI":"10.3171\/jns.1985.62.4.0475","article-title":"Neurological manifestations of the acquired immunodeficiency syndrome (AIDS): experience at UCSF and review of the literature.","volume":"62","author":"Levy","year":"1985"},{"key":"b7","series-title":"AJR","doi-asserted-by":"publisher","first-page":"977","DOI":"10.2214\/ajr.147.5.977","article-title":"Neuroradiological findings in AIDS: a review of 200 cases.","volume":"147","author":"Levy","year":"1986"},{"key":"b8","series-title":"Arch Pathol Lab Med","first-page":"867","article-title":"The neuropathology of acquired immune deficiency syndrome.","volume":"108","author":"Moskowitz","year":"1984"},{"key":"b9","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1148\/radiology.169.2.3174991","article-title":"White matter disease in AIDS: findings at MR imaging.","volume":"169","author":"Olsen","year":"1988"},{"key":"b10","series-title":"Science","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1126\/science.3277271","article-title":"AIDS. An international perspective.","volume":"239","author":"Piot","year":"1988"},{"key":"b11","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1148\/radiology.158.1.3940372","article-title":"Central nervous system disease in acquired immunodeficiency syndrome: prospective correlation using CT, MR imaging, and pathological studies.","volume":"158","author":"Post","year":"1986"},{"key":"b12","series-title":"AJR","first-page":"448","article-title":"CNS complications of AIDS: CT and MR findings.","volume":"151","author":"Ramsey","year":"1988"},{"key":"b13","series-title":"Clin Neurosurg","first-page":"419","article-title":"Neurosurgical implications of the acquired immunodeficiency syndrome (AIDS).","volume":"34","author":"Rosenblum","year":"1988"},{"key":"b14","series-title":"Ann Neurol","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1002\/ana.410230706","article-title":"Primary central nervous system lymphoma in patients with AIDS.","volume":"23","author":"Rosenblum","year":"1988"},{"key":"b15","series-title":"AJNR","first-page":"725","article-title":"Primary intracranial CNS lymphoma: MR manifestations.","volume":"10","author":"Schwaighofer","year":"1989"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/73\/5\/article-p720.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/73\/5\/article-p720.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/73\/5\/article-p720.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T01:35:40Z","timestamp":1679276140000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/73\/5\/article-p720.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":15,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/jns.1990.73.5.0720","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}