{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:15:16Z","timestamp":1780071316218,"version":"3.54.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,2]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Benign spinal nerve sheath tumors (neurofibromas and schwannomas) often occur on dorsal nerve roots sporadically or in neurofibromatosis types 1 and 2. These are histologically benign tumors, and distinction between them is frequently not made by clinicians. To determine if there is a correlation between the histological pattern of benign spinal nerve sheath tumors and the type of neurofibromatosis, the clinical and pathological features of these tumors (86 surgical specimens and five autopsies) in 68 patients were reviewed. The patients were classified into one of four categories: neurofibromatosis type 1, neurofibromatosis type 2, uncertain, or sporadic.<\/jats:p>\n<jats:p content-type=\"fine-print\">The diagnostic criteria used for neurofibromatosis types 1 and 2 were established by the National Institutes of Health. Patients who did not fulfill criteria for either neurofibromatosis type 1 or 2 but who had multiple nervous system tumors or other stigmata of neurofibromatosis were designated \u201cuncertain.\u201d Spinal nerve sheath tumors were considered sporadic in 42 cases (40 schwannomas and two neurofibromas). In the 14 patients with neurofibromatosis type 1, all spinal nerve sheath tumors were neurofibromas. In six of the seven patients with neurofibromatosis type 2, all spinal nerve sheath tumors were schwannomas. One patient with neurofibromatosis type 2 had a spinal nerve sheath schwannoma and a tumor with features of both tumor types.<\/jats:p>\n<jats:p content-type=\"fine-print\">The authors conclude that spinal nerve sheath tumors in patients with neurofibromatosis type 1 are neurofibromas. In contrast, spinal nerve sheath tumors occurring in neurofibromatosis type 2 or sporadically are most frequently schwannomas. The distinct histological features of these tumors may reflect different pathogenetic mechanisms even though they arise at identical sites in neurofibromatosis types 1 and 2.<\/jats:p>","DOI":"10.3171\/jns.1991.74.2.0248","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T16:22:33Z","timestamp":1242750153000},"page":"248-253","source":"Crossref","is-referenced-by-count":117,"title":["Benign spinal nerve sheath tumors: their occurrence sporadically and in neurofibromatosis types 1 and 2"],"prefix":"10.3171","volume":"74","author":[{"given":"Andrea L.","family":"Halliday","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond A.","family":"Sobel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Martuza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Science","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1126\/science.3107130","article-title":"Gene for von Recklinghausen neurofibromatosis is in the pericentric region of chromosome 17.","volume":"236","author":"Barker","year":"1987"},{"key":"b2","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1136\/jnnp.49.4.362","article-title":"Inherited multiple meningiomas: a clinical, pathological, and cytogenetic study of an affected family.","volume":"49","author":"Battersby","year":"1986"},{"key":"b3","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1212\/WNL.28.6.567","article-title":"Meningiomas in five members of a family over two generations, in one member simultaneously with acoustic neuromas.","volume":"28","author":"Delleman","year":"1978"},{"key":"b4","series-title":"Soft Tissue Tumors.","first-page":"580","author":"Enzinger","year":"1983"},{"key":"b5","series-title":"Ann NY Acad Sci","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1749-6632.1986.tb48070.x","article-title":"Pathology of nerve sheath tumors.","volume":"486","author":"Harkin","year":"1986"},{"key":"b6","series-title":"Pathology Annual, Part 1.","first-page":"331","article-title":"Gliomas in neurofibromatosis: a series of 89 cases with evidence for enhanced malignancy in associated cerebellar astrocytomas","volume":"20","author":"Ilgren","year":"1985"},{"key":"b7","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1212\/WNL.30.8.851","article-title":"Central neurofibromatosis with bilateral acoustic neuroma: genetic, clinical and biochemical distinctions from peripheral neurofibromatosis.","volume":"30","author":"Kanter","year":"1980"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3171\/jns.1989.71.6.0810","article-title":"Surgery of spinal nerve schannoma. 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