{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:41:36Z","timestamp":1788597696596,"version":"build-2803163510"},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Optic neuropathy induced by radiation is an infrequent cause of delayed visual loss that may at times be difficult to differentiate from compression of the visual pathways by recurrent neoplasm. The authors describe six patients with this disorder who experienced loss of vision 6 to 36 months after neurological surgery and radiation therapy. Of the six patients in the series, two had a pituitary adenoma and one each had a metastatic melanoma, multiple myeloma, craniopharyngioma, and lymphoepithelioma. Visual acuity in the affected eyes ranged from 20\/25 to no light perception. Magnetic resonance (MR) imaging showed sellar and parasellar recurrence of both pituitary adenomas, but the intrinsic lesions of the optic nerves and optic chiasm induced by radiation were enhanced after gadolinium-diethylenetriaminepenta-acetic acid (DTPA) administration and were clearly distinguishable from the suprasellar compression of tumor. Repeated MR imaging showed spontaneous resolution of gadolinium-DTPA enhancement of the optic nerve in a patient who was initially suspected of harboring recurrence of a metastatic malignant melanoma as the cause of visual loss. The authors found the presumptive diagnosis of radiation-induced optic neuropathy facilitated by MR imaging with gadolinium-DTPA. This neuro-imaging procedure may help avert exploratory surgery in some patients with recurrent neoplasm in whom the etiology of visual loss is uncertain.<\/jats:p>","DOI":"10.3171\/jns.1991.74.3.0426","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T16:16:04Z","timestamp":1242749764000},"page":"426-432","source":"Crossref","is-referenced-by-count":79,"title":["Radiation-induced optic neuropathy: a magnetic resonance imaging study"],"prefix":"10.3171","volume":"74","author":[{"given":"John","family":"Guy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Mancuso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark L.","family":"Moster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyn A.","family":"Sedwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Quisling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert L.","family":"Rhoton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene E.","family":"Protzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade","family":"Schiffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/0360-3016(77)90046-3","article-title":"The relationship of time-dose fractionation factors to complications in the treatment of pituitary tumors bv irradiation.","volume":"2","author":"Aristizabal","year":"1977"},{"key":"b2","series-title":"Int J Radiat Oncol Biol Phys","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/0360-3016(77)90007-4","article-title":"The relationship of time-dose factors to tumor control and complications in the treatment of Cushing's disease by irradiation.","volume":"2","author":"Aristizabal","year":"1977"},{"key":"b3","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1212\/WNL.4.8.575","article-title":"Intolerance of the primate brainstem and hypothalamus to conventional and high energy radiations.","volume":"4","author":"Arnold","year":"1954"},{"key":"b4","series-title":"Clin Endocrinol","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/j.1365-2265.1979.tb02103.x","article-title":"Progressive visual failure in acromegaly following external pituitary irradiation.","volume":"10","author":"Atkinson","year":"1979"},{"key":"b5","series-title":"Arch Ophthalmol","first-page":"789","article-title":"MRI in optic neuritis.","volume":"107","author":"Beck","year":"1989"},{"key":"b6","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1148\/106.1.195","article-title":"Radiation injury to large arteries.","volume":"106","author":"Benson","year":"1973"},{"key":"b7","series-title":"AJR","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2214\/ajr.134.1.51","article-title":"Radiation-induced large intracranial vessel occlusive vasculopathy.","volume":"134","author":"Brant-Zawadzki","year":"1980"},{"key":"b8","series-title":"AJR","doi-asserted-by":"publisher","first-page":"625","DOI":"10.2214\/ajr.142.3.625","article-title":"Contrast-enhanced NMR imaging: animal studies using gadolinium-DTPA complex.","volume":"142","author":"Brasch","year":"1984"},{"key":"b9","series-title":"Ophthalmology","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1016\/S0161-6420(82)34612-6","article-title":"Radiation optic neuropathy.","volume":"89","author":"Brown","year":"1982"},{"key":"b10","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1002\/1097-0142(197511)36:5<1702::AID-CNCR2820360525>3.0.CO;2-V","article-title":"Delayed cerebrovascular consequences of therapeutic radiation: a clinicopathologic study of a stroke associated with radiation-related carotid arteriopathy.","volume":"36","author":"Conomy","year":"1975"},{"key":"b11","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1148\/radiology.158.1.3940373","article-title":"Brain radiation lesions: MR imaging.","volume":"158","author":"Dooms","year":"1986"},{"key":"b12","series-title":"Arch Ophthalmol","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1001\/archopht.1981.03930010611005","article-title":"Radiation therapy in and about the retina, optic nerve, and anterior visual pathway. 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