{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T17:42:09Z","timestamp":1793727729944,"version":"4.6.1"},"reference-count":106,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The clinical, radiographic, and pathological findings in 155 patients with symptomatic Rathke's cleft cysts are discussed. Eight patients were treated by the authors and 147 were collected in a review of the literature. This lesion occurred more often in female than male patients by a 2:1 margin, and the mean age at presentation was 38 years. The average patient had been symptomatic for nearly 3 years at the time of treatment, with the most common symptoms and signs being pituitary dysfunction, visual disturbances, and headaches. Affected children generally were pituitary dwarfs. The sella was enlarged in 80% of cases, and the cyst was situated in both an intrasellar and a suprasellar location in 71%. Computerized tomography revealed a low-density cystic mass with capsular enhancement in one-half of the cases. A variable appearance was seen with magnetic resonance imaging. Partial excision and drainage of the cyst by the transsphenoidal approach is the recommended treatment, as the recurrence rate is low. Most symptoms and signs improved or resolved following surgery with the exception of hypopituitarism and diabetes insipidus. The cyst lining was usually composed of ciliated cuboidal or columnar epithelium. Theories as to the origin of Rathke's cleft cysts are also discussed.<\/jats:p>","DOI":"10.3171\/jns.1991.74.4.0535","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T12:20:37Z","timestamp":1242735637000},"page":"535-544","source":"Crossref","is-referenced-by-count":238,"title":["Clinical, radiographic, and pathological features of symptomatic Rathke's cleft cysts"],"prefix":"10.3171","volume":"74","author":[{"given":"Joseph L.","family":"Voelker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jans","family":"Muller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","first-page":"641","article-title":"Calcification in Rathke's cleft cysts.","volume":"47","author":"Adelman","year":"1977"},{"key":"b2","series-title":"J Neurosurg Sci","first-page":"65","article-title":"Epithelial cysts related to the Rathke's cleft.","volume":"18","author":"Agnetti","year":"1974"},{"key":"b3","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1227\/00006123-198801010-00022","article-title":"Triad of hypopituitarism, granulomatous hypophysitis, and ruptured Rathke's cleft cyst.","volume":"22","author":"Albini","year":"1988"},{"key":"b4","series-title":"Arch Dis Child","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1136\/adc.22.110.118","article-title":"Dysontogenetic pituitary cysts (pituitary cachexia in childhood).","volume":"22","author":"Baar","year":"1947"},{"key":"b5","series-title":"Cytology and Cellular Pathology of the Nervous System.","first-page":"1133","article-title":"Tumors of the hypophysis cerebri","author":"Bailey","year":"1932"},{"key":"b6","series-title":"Acta Neurochir","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/BF02074522","article-title":"The empty sella syndrome secondary to Rathke's cleft cyst.","volume":"53","author":"Baldini","year":"1980"},{"key":"b7","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1227\/00006123-198506000-00005","article-title":"Symptomatic Rathke's cleft cysts located entirely in the suprasellar region: review of diagnosis, management, and pathogenesis.","volume":"16","author":"Barrow","year":"1985"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"8","DOI":"10.3171\/jns.1984.60.1.0008","article-title":"Transsphenoidal treatment of non-neoplastic intrasellar cysts. 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