{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T09:06:47Z","timestamp":1749632807232},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Tissue markers of cellular proliferation have been recently utilized as prognostic indicators in tumors of the central nervous system. Nucleolar organizer regions represent transcriptionally active sites of ribosomal deoxyribonucleic acid (DNA) and can be identified by a simple argyrophilic technique. The authors describe a standardized approach to the assessment of these argyrophilic nucleolar organizer regions in meningeal tumors. Twenty-five meningiomas were classified histologically into benign, atypical, or malignant groups. In addition, two hemangiopericytomas and one leptomeningeal melanoma were examined. Appropriate sections were silver stained and argyrophilic nucleolar organizer regions were counted in 200 nuclei. The mean argyrophilic nucleolar organizer region count was statistically different (p &lt; 0.001) between benign tumors (245 \u00b1 156, 1.23\/cell), atypical tumors (497 \u00b1 135, 2.49\/cell), and malignant tumors (921 \u00b1 59, 4.61\/cell). The count for recurrent meningiomas (544 \u00b1 76) was also statistically different (p &lt; 0.02) from non-recurrent tumors (329 \u00b1 183). The standardized assessment of argyrophilic nucleolar organizer regions can be easily performed by any surgical pathology laboratory without specialized equipment and, in meningeal tumors, may be useful as an independent indicator of biological behavior.<\/jats:p>","DOI":"10.3171\/jns.1991.74.4.0590","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T16:20:37Z","timestamp":1242750037000},"page":"590-596","source":"Crossref","is-referenced-by-count":15,"title":["The standardized assessment of argyrophilic nucleolar organizer regions in meningeal tumors"],"prefix":"10.3171","volume":"74","author":[{"given":"Lawrence S.","family":"Chin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Hinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Pathol","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1136\/jcp.42.9.1002-b","article-title":"Value of AgNOR method in predicting recurrence of meningioma.","volume":"42","author":"Boon","year":"1989"},{"key":"b2","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"52","DOI":"10.3171\/jns.1984.60.1.0052","article-title":"Morbidity, mortality, and quality of life following surgery for intracranial meningiomas. 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