{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:12:53Z","timestamp":1792613573725,"version":"4.5.0"},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Conductance of cerebrospinal fluid (CSF) outflow (C<jats:sub>out<\/jats:sub>) is an important parameter to be considered in patients with CSF circulation abnormalities. In patients with normal-pressure hydrocephalus it is the single most important parameter in determining if the patient needs CSF shunting. The lower normal limit for C<jats:sub>out<\/jats:sub> has been estimated from the effect of shunting in patients with normal-pressure hydrocephalus, from patients retrospectively reevaluated after recovering from illness, and from patients with known abnormalities in the brain or the CSF system. The true value of C<jats:sub>out<\/jats:sub> in normal individuals, however, has hitherto not been reported.<\/jats:p>\n<jats:p>In the present study, C<jats:sub>out<\/jats:sub> has been measured by a lumbar infusion test in eight young volunteers with no suspicion of disease. The mean intracranial pressure (ICP) was 11 mm Hg and a linear relationship was found between CSF absorption and ICP. The mean C<jats:sub>out<\/jats:sub> was 0.11 ml\/min\/mm Hg and the lower 95% confidence level was 0.10 ml\/min\/mm Hg. These values are in accordance with those obtained from previous studies.<\/jats:p>","DOI":"10.3171\/jns.1991.74.4.0597","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T16:20:37Z","timestamp":1242750037000},"page":"597-600","source":"Crossref","is-referenced-by-count":163,"title":["Intracranial pressure and cerebrospinal fluid outflow conductance in healthy subjects"],"prefix":"10.3171","volume":"74","author":[{"given":"Michael J.","family":"Albeck","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svend E.","family":"B\u00f8rgesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flemming","family":"Gjerris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes F.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per Soelberg","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Brain","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1093\/brain\/105.1.65","article-title":"The predictive value of conductance to outflow of CSF in normal pressure hydrocephalus.","volume":"105","author":"B\u00f8rgesen","year":"1982"},{"key":"b2","series-title":"Outflow of Cerebrospinal Fluid.","first-page":"121","article-title":"Measurement of resistance to CSF outflow by subarachnoid perfusion","author":"B\u00f8rgesen","year":"1989"},{"key":"b3","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"521","DOI":"10.3171\/jns.1979.51.4.0521","article-title":"Cerebrospinal fluid conductance and compliance of the craniospinal space in normal-pressure hydrocephalus. 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A method of evaluation by lumbo-ventricular perfusion, with particular reference to normal pressure hydrocephalus.","volume":"57","author":"B\u00f8rgesen","year":"1978"},{"key":"b5","series-title":"Des Med Child Neurol","first-page":"71","article-title":"Lumbar subarachnoid infusion test in paediatric neurosurgery.","volume":"21","author":"Caldarelli","year":"1979"},{"key":"b6","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1093\/bja\/61.3.340","article-title":"Prophylactic extradural blood patch is effective.","volume":"61","author":"Cheek","year":"1988"},{"key":"b7","series-title":"Brain","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1093\/brain\/91.4.707","article-title":"Formation and absorption of cerebrospinal fluid in man.","volume":"91","author":"Cutler","year":"1968"},{"key":"b8","series-title":"Physiology and Pathophysiology of the Cerebrospinal Fluid.","first-page":"485","author":"Davson","year":"1987"},{"key":"b9","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3171\/jns.1974.40.3.0381","article-title":"Cerebrospinal fluid overproduction and hydrocephalus associated with choroid plexus papilloma.","volume":"40","author":"Eisenberg","year":"1974"},{"key":"b10","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1136\/jnnp.41.4.345","article-title":"CSF hydrodynamic studies in man. 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