{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:11:02Z","timestamp":1782951062323,"version":"3.54.5"},"reference-count":21,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Angiosarcoma arising in the central or peripheral nervous system has rarely been reported. Eight patients with primary angiosarcoma of the central nervous system are described here; these included five males and three females ranging in age from 2 weeks to 72 years (mean 38 years). Of the eight neoplasms, six were located in the cerebral hemispheres and one was in the meninges; the site was unknown in the other. All patients underwent surgical resection. Five of the eight patients died, four within 4 months after surgery and one after 30 months. Two of the remaining three patients were 17 and 27 years old at the time of diagnosis and were alive at follow-up review 39 and 102 months after surgery, respectively. One patient was lost to follow-up monitoring.<\/jats:p>\n<jats:p content-type=\"fine-print\">Microscopically, all eight tumors demonstrated a well-differentiated pattern with irregular vascular channels and intraluminal papillae; in addition, four showed poorly differentiated solid areas. Immunohistochemical staining of neoplastic cells to factor VIII-related antigen and <jats:italic>Ulex europaeus<\/jats:italic> agglutinin I was performed in five tumors and was focally positive in four. No correlation could be shown between the histological features and the growth and biological behavior of the tumors.<\/jats:p>","DOI":"10.3171\/jns.1991.75.1.0073","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T16:22:46Z","timestamp":1242750166000},"page":"73-76","source":"Crossref","is-referenced-by-count":62,"title":["Primary angiosarcoma of the central nervous system"],"prefix":"10.3171","volume":"75","author":[{"given":"Hernando","family":"Mena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz M.","family":"Enzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Parisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","first-page":"1121","article-title":"Immunohistochemistry of central nervous system tumors. 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Light and electron microscopic features.","volume":"42","author":"Mena","year":"1978"},{"key":"b15","series-title":"Amer J Clin Pathol","first-page":"32","article-title":"Ulex europaeus I lectin as a marker for tumors derived from endothelial cells.","volume":"79","author":"Miettinen","year":"1983"},{"key":"b16","series-title":"Arch Pathol Lab Med","first-page":"129","article-title":"Comparison of Ulex europaeus I lectin and factor VIII-related antigen in vascular lesions.","volume":"108","author":"Ord\u00f3\u00f1ez","year":"1984"},{"key":"b17","series-title":"Arch Pathol Lab Med","first-page":"796","article-title":"Recent applications of immunoperoxidase histochemistry in human neuro-oncology.","volume":"111","author":"Perentes","year":"1987"},{"key":"b18","series-title":"Pathology of Tumours of the Nervous System","first-page":"657","author":"Russell","year":"1989"},{"key":"b19","series-title":"J Pathol","first-page":"289","article-title":"Hemangiosarcoma of the breast.","volume":"74","author":"Shore","year":"1957"},{"key":"b20","series-title":"Br J Surg","first-page":"465","article-title":"Metastasizing hemangiomata: a case of malignant hemangio-endothelioma.","volume":"40","author":"Tibbs","year":"1953"},{"key":"b21","series-title":"Pathology Annual, Part 2.","first-page":"279","article-title":"The ultrastructure of vascular tumors: additional observations and a review of the literature","author":"Waldo","year":"1977"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/75\/1\/article-p73.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/75\/1\/article-p73.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/75\/1\/article-p73.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T21:55:52Z","timestamp":1679262952000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/75\/1\/article-p73.xml"}},"subtitle":["Study of eight cases and review of the literature"],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":21,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1991.75.1.0073","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}