{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:07:43Z","timestamp":1768442863368,"version":"3.49.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1991,10]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The term \u201cangioglioma\u201d denotes a highly vascular glioma, most of which are low-grade lesions associated with a favorable prognosis. The authors encountered an example of this pathology, a cystic oligodendroglioma associated with prominent vasculature which both clinically and histologically mimicked an occult arteriovenous malformation (AVM). This case and reports of the association of AVM and glioma prompted a histological review of 1034 surgically resected AVM's, both angiographically occult and visible, among which no oligodendroglial or astrocytic forms of \u201cangioglioma\u201d were found. Eight cases were observed, however, wherein oligodendroglial cells were increased in number within or about the malformation. Two basic histological patterns of oligodendroglial cell excess were seen; one appeared to be malformative in nature with abnormal disposition of oligodendroglial cells being an integral part of the AVM, whereas in the other an apparent increase in cellularity seemed the result of chronic ischemia with condensation of white matter. It appeared that the areas of increased oligodendrocyte content seen in association with AVM are non-neoplastic lesions that exhibit two rather distinct histological patterns of differing origin.<\/jats:p>\n<jats:p content-type=\"fine-print\">In an effort to determine the frequency of \u201cangioglioma,\u201d the authors examined Tissue Registry data for several glioma groups in which highly vascular examples are prone to occur. Tumors selected for study included 104 cerebellar-type (pilocytic) astrocytomas, 82 oligodendrogliomas, and 51 supratentorial pilocytic astrocytomas. Histological hypervascularity mimicking a vascular malformation (that is, an \u201cangioglioma\u201d) was encountered in 5%, 4%, and 12% of the cases, respectively. Based upon clinical, radiological, and pathological reviews of these cases, as well as a careful review of the literature, it was concluded that 1) \u201cangiogliomas\u201d are neither rare nor represent a distinct clinicopathological entity; 2) in histological but not necessarily angiographic surgical terms, they represent simply highly vascular gliomas, usually of low grade; and 3) the clinicopathological and angiographic features as well as the prognosis of such lesions do not differ from those of similar gliomas without angioma-like vasculature. Finally, \u201cangiogliomas\u201d must not be confused with gliomas of high-grade malignancy which, due to neovascularity, may be highly vascular at angiography and at surgery.<\/jats:p>","DOI":"10.3171\/jns.1991.75.4.0589","type":"journal-article","created":{"date-parts":[[2009,5,19]],"date-time":"2009-05-19T16:21:29Z","timestamp":1242750089000},"page":"589-596","source":"Crossref","is-referenced-by-count":47,"title":["\u201cAngioglioma\u201d and the arteriovenous malformationglioma association"],"prefix":"10.3171","volume":"75","author":[{"given":"Daniela","family":"Lombardi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd W.","family":"Scheithauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Piepgras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredric B.","family":"Meyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Glenn S.","family":"Forbes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neuropathol Exp Neurol","first-page":"504","article-title":"Mixed capillary hemangioblastoma and glioma. A redefinition of the \u201cangioglioma.\u201d","volume":"42","author":"Bonnin","year":"1983"},{"key":"b2","series-title":"J Neurosurg","first-page":"145","article-title":"Oligodendroglioma and cerebral cavernous angioma. Case report.","volume":"62","author":"Chee","year":"1985"},{"key":"b3","series-title":"Neurosurgery","first-page":"241","article-title":"Association of a ganglioneuroma with an arteriovenous malformation: case report.","volume":"21","author":"Chovanes","year":"1987"},{"key":"b4","series-title":"Long Island Med J","first-page":"401","article-title":"The gliomatous tumors of the brain.","volume":"8","author":"Councilman","year":"1914"},{"key":"b5","series-title":"J Neurosurg","first-page":"108","article-title":"Arteriovenous malformation and oligodendroglioma. Case report.","volume":"43","author":"Crowell","year":"1975"},{"key":"b6","series-title":"Scott Med J","first-page":"342","article-title":"Recurrent attacks of subarachnoid haemorrhage in presence of a cerebral angioma and an intraventricular oligodendroglioma.","volume":"5","author":"Fine","year":"1960"},{"key":"b7","series-title":"J Neurosurg","first-page":"430","article-title":"Cerebral hemangioma with glial neoplasia (angioglioma?). Report of two cases.","volume":"56","author":"Fischer","year":"1982"},{"key":"b8","series-title":"No Shinkei Geka","first-page":"175","article-title":"[The association of intracranial meningioma with arteriovenous malformation and aneurysm. Report of a case.]","volume":"5","author":"Fukawa","year":"1977"},{"key":"b9","series-title":"J Neurosurg","first-page":"798","article-title":"Arteriovenous malformation and glioma: coexistent or sequential?","volume":"72","author":"Goodkin","year":"1990"},{"key":"b10","series-title":"J Neurosurg","first-page":"229","article-title":"Benign astrocytoma associated with arteriovenous malformation. Case report.","volume":"35","author":"Heffner","year":"1971"},{"key":"b11","series-title":"Cancer","first-page":"2913","article-title":"Concurrence of multiple sclerosis and primary intracranial neoplasms.","volume":"47","author":"Ho","year":"1981"},{"key":"b12","series-title":"J Surg Oncol","first-page":"35","article-title":"Lipomatous meningioma associated with cerebral vascular malformation.","volume":"26","author":"Kasantikul","year":"1984"},{"key":"b13","series-title":"J Neurosurg","first-page":"81","article-title":"Combined neurilemmoma and angioma. Tumor of ectomesenchyme and a source of bleeding.","volume":"50","author":"Kasantikul","year":"1979"},{"key":"b14","series-title":"Acta Neurochir","first-page":"38","article-title":"Management of associated primary cerebral neoplasms and vascular malformations. 2. Intracranial arterio-venous malformations.","volume":"83","author":"Licata","year":"1986"},{"key":"b15","series-title":"Neurosurgery","first-page":"125","article-title":"Subarachnoid hemorrhage in the presence of a cerebral arteriovenous malformation and an intraventricular oligodendroglioma: case report.","volume":"19","author":"Martinez-Lage","year":"1986"},{"key":"b16","series-title":"Acta Neurochir","first-page":"53","article-title":"Craniopharyngioma with unusual topography and associated with vascular pathology.","volume":"53","author":"Mori","year":"1980"},{"key":"b17","series-title":"Neurosurgery","first-page":"781","article-title":"Oligodendroglial proliferative abnormality associated with arteriovenous malformation: report of three cases with review of the literature.","volume":"23","author":"Nazek","year":"1988"},{"key":"b18","series-title":"No Shinkei Geka","first-page":"215","article-title":"[A meningioma associated with AVM: a case report.]","volume":"14","author":"Ohno","year":"1986"},{"key":"b19","series-title":"Arch Neurol","first-page":"39","article-title":"Hemangioblastoma and vascular malformations as one lesion.","volume":"12","author":"Raynor","year":"1965"},{"key":"b20","series-title":"Presse Med","first-page":"179","article-title":"Les tumeurs angiomateuses des centres nerveux.","volume":"38","author":"Roussy","year":"1930"},{"key":"b21","series-title":"Tumors of the Central Nervous System. Atlas of Tumor Pathology. Series 2, Fascicle 6.","author":"Rubinstein","year":"1972"},{"key":"b22","series-title":"Pathology of Tumours of the Nervous System","author":"Russell","year":"1989"},{"key":"b23","series-title":"IMJ","first-page":"388","article-title":"Intracranial vascular malformation and astrocytoma.","volume":"168","author":"Shah","year":"1985"},{"key":"b24","series-title":"J Neurosurg","first-page":"618","article-title":"Intracranial arteriovenous malformation, pulmonary arteriovenous fistula, and malignant glioma in the same patient. Case report.","volume":"30","author":"Warren","year":"1969"},{"key":"b25","series-title":"Dtsch Z Nervenheilk","first-page":"231","article-title":"Kombination eines Angioma arteriovenosum aneurysmaticum mit einem Astrocytom.","volume":"189","author":"Welcker","year":"1966"},{"key":"b26","series-title":"J Neuropathol Exp Neurol","first-page":"392","article-title":"A study of fifty intracranial vascular tumors found incidentally at necropsy.","volume":"17","author":"White","year":"1958"},{"key":"b27","series-title":"Acta Neurochir","first-page":"305","article-title":"Malignant astrocytoma associated with arteriovenous malformation. Case report.","volume":"50","author":"Zuccarello","year":"1979"},{"key":"b28","series-title":"Histological Typing of Tumours of the Central Nervous System.","author":"Z\u00fclch","year":"1979"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/75\/4\/article-p589.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/75\/4\/article-p589.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/75\/4\/article-p589.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T22:24:37Z","timestamp":1679264677000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/75\/4\/article-p589.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10]]},"references-count":28,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/jns.1991.75.4.0589","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1991,10]]}}}