{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:30:10Z","timestamp":1791300610322,"version":"4.1.0"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 An investigation into the role of intravenous fluid tonicity in determining intracranial pressure (ICP) after brain injury is described. The authors compare the results of infusion of a hypotonic fluid (Ringer's lactate, 270 mOsm\/liter) to those of a hypertonic fluid (hypertonic sodium lactate, 500 mOsm\/liter) in a porcine model of focal cryogenic brain injury. Hemodynamic parameters (ICP, regional cerebral blood flow (CBF), and oxygen delivery) and serum osmolarity were measured every 3 hours for 24 hours after injury. At sacrifice, the water content of the lesioned and nonlesioned cortex was determined by specific gravity. The cryogenic injury produced a significant increase in ICP and a significant decrease in CBF in all experimental groups. Maintenance infusion of hypertonic sodium lactate for 24 hours resulted in significantly lower ICP, higher CBF and oxygen delivery, and higher serum osmolarity than Ringer's lactate infusion. Cortical water content in the area of the lesion was similar in both groups, but in the uninjured hemisphere it was significantly lower in the hypertonic group. These data suggest that hypertonic maintenance fluid improves intracranial compliance by dehydrating uninjured cortex. Improved CBF in the hypertonic group may be due to dehydration of cerebrovascular endothelium and erythrocytes. By reducing ICP and improving CBF, hypertonic fluid administration may thus reduce secondary brain injury after head trauma.<\/jats:p>","DOI":"10.3171\/jns.1992.76.1.0091","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T14:54:35Z","timestamp":1243436075000},"page":"91-98","source":"Crossref","is-referenced-by-count":158,"title":["Intravenous fluid tonicity: effect on intracranial pressure, cerebral blood flow, and cerebral oxygen delivery in focal brain injury"],"prefix":"10.3171","volume":"76","author":[{"given":"Steven R.","family":"Shackford","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Schmoker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Clin Pathol","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1136\/jcp.33.12.1132","article-title":"Brain damage in fatal non-missile head injury.","volume":"33","author":"Adams","year":"1980"},{"key":"b2","series-title":"Surg Gynecol Obstet","first-page":"48","article-title":"The effects of intravenous fluids on cerebrospinal fluid pressure.","volume":"99","author":"Bakay","year":"1954"},{"key":"b3","series-title":"J Trauma","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1097\/00005373-198810000-00010","article-title":"Base deficit as a guide to volume resuscitation.","volume":"28","author":"Davis","year":"1988"},{"key":"b4","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1097\/00000658-193501000-00011","article-title":"The treatment of acute and chronic cases of cerebral trauma, by methods of dehydration.","volume":"101","author":"Fay","year":"1935"},{"key":"b5","series-title":"Neurol Res","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1080\/01616412.1981.11739609","article-title":"Factors in the reproducibility of the gravimetric method for evaluation of edematous changes in the brain.","volume":"3","author":"Fujiwara","year":"1981"},{"key":"b6","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/0022-510X(78)90124-7","article-title":"Ischaemic brain damage in fatal non-missile head injuries.","volume":"39","author":"Graham","year":"1978"},{"key":"b7","series-title":"Surgery","first-page":"398","article-title":"Head injury and hemorrhagic shock: studies of the blood brain barrier and intracranial pressure after resuscitation with normal saline solution, 3% saline solution, and dextran-40.","volume":"103","author":"Gunnar","year":"1988"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"246","DOI":"10.3171\/jns.1982.56.2.0246","article-title":"An improved gravimetric measure of cerebral edema.","volume":"56","author":"Marmarou","year":"1982"},{"key":"b9","series-title":"Am J Physiol","first-page":"H629","article-title":"Dynamic fluid redistribution in hyperosmotic resuscitation of hypovolemic hemorrhage.","volume":"255","author":"Mazzoni","year":"1988"},{"key":"b10","series-title":"J Cell Physiol","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1002\/jcp.1041400212","article-title":"Volume changes of an endothelial cell monolayer on exposure to anisotonic media.","volume":"140","author":"Mazzoni","year":"1989"},{"key":"b11","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1001\/jama.1978.03290050029011","article-title":"Early insults to the injured brain.","volume":"240","author":"Miller","year":"1978"},{"key":"b12","series-title":"Crit Care Med","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1097\/00003246-198507000-00011","article-title":"Effect of hydration on experimentally induced cerebral edema.","volume":"13","author":"Morse","year":"1985"},{"key":"b13","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3171\/jns.1987.67.2.0206","article-title":"Continuous monitoring of intracranial pressure with a miniaturized fiberoptic device.","volume":"67","author":"Ostrup","year":"1987"},{"key":"b14","series-title":"Textbook of Head Injury.","first-page":"192","article-title":"Medical management of head injuries","author":"Pacult","year":"1989"},{"key":"b15","series-title":"Stroke","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1161\/01.STR.4.4.556","article-title":"The hydrogen clearance method in assessment of blood flow in cortex, white matter and deep nuclei of baboons.","volume":"4","author":"Pasztor","year":"1973"},{"key":"b16","series-title":"Br J Anaesth","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1093\/bja\/48.8.741","article-title":"Vasogenic brain oedema. 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