{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:34:43Z","timestamp":1783082083400,"version":"3.54.6"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1992,6]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Neurovascular decompression is a widely practiced tec hnique for the treatment of trigeminal neuralgia, and yet there is still debate as to whether the beneficial effect results from relieving the nerve of compression by an anatomically abnormal vessel or from the manipulation and trauma the nerve undergoes during the procedure. The development of this operation has been hampered by the lack of adequate anatomical studies in normal controls. The authors present a combined study of clinical and anatomical material employing standardized definitions of the neurovascular relationships in both groups. Detailed simulations of the operative procedure were carried out on fresh cadavers matched for age, sex, and side, and a technique of <jats:italic>in situ<\/jats:italic> blood vessel perfusion was developed that enabled the normal neurovascular arrangement to be observed post mortem at physiological pressures.<\/jats:p>\n<jats:p content-type=\"fine-print\">Neurovascular compression, typified by a large vessel distorting and creating a groove in the fifth cranial nerve, was found in 37 of the 41 cases of trigeminal neuralgia; recurrence of pain did not relate to the site of compression. A follow-up study was carried out for a median of 53 months (range 12 to 103 months). No distortion was found in a total of 50 normal cadaveric dissections; however, on perfusion to physiological pressures, the percentage of nerves with vessels adjacent or in simple contact increased from 16% to 40%. This study using this new technique confirms that vascular compression of the fifth cranial nerve is an anatomical abnormality specific to trigeminal neuralgia.<\/jats:p>","DOI":"10.3171\/jns.1992.76.6.0948","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T02:57:08Z","timestamp":1243393028000},"page":"948-954","source":"Crossref","is-referenced-by-count":154,"title":["Neurovascular compression in trigeminal neuralgia: a clinical and anatomical study"],"prefix":"10.3171","volume":"76","author":[{"given":"Peter J.","family":"Hamlyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3171\/jns.1989.70.1.0001","article-title":"Microvascular compression: an alternative view and hypothesis.","volume":"70","author":"Adams","year":"1989"},{"key":"b2","series-title":"J Neurosurg","first-page":"463","article-title":"Views on microvascular compression.","volume":"71","author":"Adams","year":"1989"},{"key":"b3","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1136\/jnnp.45.11.1020","article-title":"The treatment of trigeminal neuralgia by posterior fossa microsurgery.","volume":"45","author":"Adams","year":"1982"},{"key":"b4","series-title":"J Neurosurg","first-page":"462","article-title":"Views on microvascular compression.","volume":"71","author":"Ambrosetto","year":"1989"},{"key":"b5","series-title":"Clin Neurosurg","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1093\/neurosurgery\/31.CN_suppl_1.351","article-title":"Surgery for tic douloureaux.","volume":"31","author":"Apfelbaum","year":"1984"},{"key":"b6","series-title":"J Neurosurg","first-page":"461","article-title":"Views on microvascular compression.","volume":"71","author":"Apfelbaum","year":"1989"},{"key":"b7","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"104","DOI":"10.3171\/jns.1984.60.1.0104","article-title":"Success of microvascular decompression with and without prior surgical therapy for trigeminal neuralgia.","volume":"60","author":"Barba","year":"1984"},{"key":"b8","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3171\/jns.1988.69.1.0035","article-title":"Long-term efficacy of microvascular decompression in trigeminal neuralgia.","volume":"69","author":"Burchiel","year":"1988"},{"key":"b9","series-title":"Am J Surg","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0002-9610(34)90403-7","article-title":"Concerning the cause of trigeminal neuralgia.","volume":"24","author":"Dandy","year":"1934"},{"key":"b10","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.1001\/jama.1959.03010150017004","article-title":"Response of trigeminal neuralgia to \u201cdecompression\u201d of sensory root. 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A five-year follow-up study.","volume":"22","author":"Kolluri","year":"1984"},{"key":"b19","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1227\/00006123-198906000-00016","article-title":"The microsurgical anatomy of the infratentorial lateral supracerebellar approach to the trigeminal nerve for tic douloureux.","volume":"24","author":"Matsushima","year":"1989"},{"key":"b20","series-title":"Saudi Med J","first-page":"213","article-title":"Superior cerebellar artery in the pontine zone.","volume":"2","author":"Mehta","year":"1981"},{"key":"b21","series-title":"J Neurosurg","first-page":"459","article-title":"Views on microvascular compression.","volume":"71","author":"M\u00f8ller","year":"1989"},{"key":"b22","series-title":"Arch Neurol","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1001\/archneur.1985.04210090069019","article-title":"Case against microvascular decompression in the treatment of trigeminal neuralgia.","volume":"42","author":"Morley","year":"1985"},{"key":"b23","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1136\/jnnp.46.12.1098","article-title":"Operative findings on microsurgical exploration of the cerebello-pontine angle in trigeminal neuralgia.","volume":"46","author":"Richards","year":"1983"},{"key":"b24","series-title":"J Neurosurg","first-page":"463","article-title":"Views on microvascular compression.","volume":"71","author":"Silbergeld","year":"1989"},{"key":"b25","series-title":"J Neurol Neurosurg Psychiatry","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1136\/jnnp.11.4.243","article-title":"Neurovascular relations and anomalies at base of brain.","volume":"11","author":"Sunderland","year":"1948"},{"key":"b26","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1227\/00006123-198512000-00009","article-title":"Prognostic factors in microvascular decompression for trigeminal neuralgia.","volume":"17","author":"Szapiro","year":"1985"},{"key":"b27","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3171\/jns.1982.57.6.0757","article-title":"A 10-year experience in the treatment of trigeminal neuralgia. Comparison of percutaneous stereotaxic rhizotomy and posterior fossa exploration.","volume":"57","author":"van Loveren","year":"1982"},{"key":"b28","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1212\/WNL.34.10.1362","article-title":"Outcome following microsurgical vascular decompression of partial sensory rhizotomy in 125 cases of trigeminal neuralgia.","volume":"34","author":"Zorman","year":"1984"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/76\/6\/article-p948.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/76\/6\/article-p948.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/76\/6\/article-p948.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T00:39:06Z","timestamp":1679272746000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/76\/6\/article-p948.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,6]]},"references-count":28,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/jns.1992.76.6.0948","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1992,6]]}}}