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Even after adjustment for covariate factors such as age, sex, smoking habits, alcohol use, antiepileptic medications, and tumor grade, there still remained a highly significant dose-dependent inverse relationship between constitutive and hydrogen peroxide-induced mononuclear leukocyte ADP-ribosylation levels and the duration of corticosteroid treatment (beta coefficients \u22120.40 and \u22120.29, respectively; p &lt; 0.03). No other variable under consideration significantly influenced ADP-ribosylation levels after statistical adjustment. 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