{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:08:37Z","timestamp":1776287317925,"version":"3.50.1"},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,4]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 This study examines whether platelet-activating factor (PAF) is involved in the occurrence of vasospasm after subarachnoid hemorrhage (SAH). A vasospasm model was produced in rabbits, with animals in six experimental groups receiving two subarachnoid injections of autologous arterial blood with the addition of one of the following: saline (Control Group 1), 25% dimethyl sulfoxide (Control Group 2), PAF (1, 2.5, 5, or 10 \u00b5g), CV6209 (10 or 100 \u00b5g), BN52021 (10 or 100 \u00b5g), or anti-PAF immunoglobulin G (IgG, 50 or 500 \u00b5g). No significant differences were detected between Control Groups 1 and 2 with regard to neurological deterioration and basilar artery constriction after SAH was induced. Administration of PAF together with autologous blood aggravated neurological deficits in a dose-dependent manner (r = 0.724, p &lt; 0.001) and produced basilar artery constriction at two doses each of 2.5 \u00b5g (p &lt; 0.05), 5 \u00b5g (p &lt; 0.01), and 10 \u00b5g (p &lt; 0.01). Neurological deterioration was prevented in rabbits receiving an intracisternal administration of either PAF antagonist CV6209 or BN52021 or anti-PAF IgG (p &lt; 0.01 at a total dose of 20 \u00b5g and p &lt; 0.05 at a total dose of 200 \u00b5g CV6209, p &lt; 0.01 at total doses of 20 and 200 \u00b5g BN52021, and p &lt; 0.01 at total doses of 100 and 1000 \u00b5g anti-PAF IgG). A reduction in basilar artery constriction was achieved by the injection of anti-PAF IgG (p &lt; 0.05 at total doses of 100 and 1000 \u00b5g). Histological examination at autopsy on Days 14 to 21 showed mainly ischemic changes in the brain, including selective neuronal necrosis and cerebral infarction. The control and PAF groups showed marked ischemic changes. On the other hand, no ischemic changes were noted in the anti-PAF IgG group, and only 9% of animals in the CV6209 group and 25% in the BN52021 group demonstrated selective neuronal necrosis or infarction. This study thus provides evidence to support the role of PAF in the pathogenesis of vasospasm after SAH.<\/jats:p>","DOI":"10.3171\/jns.1993.78.4.0592","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T15:15:10Z","timestamp":1243437310000},"page":"592-597","source":"Crossref","is-referenced-by-count":29,"title":["Platelet-activating factor and cerebral vasospasm following subarachnoid hemorrhage"],"prefix":"10.3171","volume":"78","author":[{"given":"Yutaka","family":"Hirashima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunro","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuneo","family":"Otsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoshichi","family":"Nojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Takaku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"N Engl J Med","first-page":"619","article-title":"Cerebral arterial spasm \u2014 a controlled trial of nimodipine in patients with subarachnoid hemorrhage.","volume":"308","author":"Allen","year":"1983"},{"key":"b2","series-title":"Pharmacol Rev","first-page":"97","article-title":"Perspectives in platelet-activating factor research.","volume":"39","author":"Braquet","year":"1987"},{"key":"b3","series-title":"Platelet Activating Factor in Human Diseases.","first-page":"23","article-title":"Cellular origin of PAF","author":"Bratton","year":"1989"},{"key":"b4","series-title":"Biochem Biophys Res Commun","first-page":"730","article-title":"Presence of specific binding sites for platelet-activating factor (PAF) in brain.","volume":"151","author":"Domingo","year":"1988"},{"key":"b5","series-title":"J Am Stat Assoc","first-page":"1096","article-title":"A multiple comparison procedure for comparing several treatments with a control.","volume":"50","author":"Dunnet","year":"1955"},{"key":"b6","series-title":"J Biol Chem","first-page":"7329","article-title":"Mechanism for irreversible self-deactivation of prostaglandin synthetase.","volume":"251","author":"Egan","year":"1976"},{"key":"b7","series-title":"Stroke","first-page":"1420","article-title":"Experimental model of symptomatic vasospasm in rabbits.","volume":"19","author":"Endo","year":"1988"},{"key":"b8","series-title":"Stroke","first-page":"III90","article-title":"Platelet-activating factor. 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An experimental study.","volume":"49","author":"Tanabe","year":"1978"},{"key":"b23","series-title":"Biometrics","first-page":"259","article-title":"Individual comparisons bv ranking methods.","volume":"1","author":"Wilcoxon","year":"1945"},{"key":"b24","series-title":"Stroke","first-page":"527","article-title":"Biosynthesis of leukotrienes in canine cerebral vasospasm.","volume":"20","author":"Yokota","year":"1989"},{"key":"b25","series-title":"J Neurochem","first-page":"1809","article-title":"Production of plateletactivating factor from rat cerebellar granule cells in culture.","volume":"54","author":"Yue","year":"1990"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/78\/4\/article-p592.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/78\/4\/article-p592.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/78\/4\/article-p592.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T21:09:11Z","timestamp":1679260151000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/78\/4\/article-p592.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4]]},"references-count":25,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/jns.1993.78.4.0592","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1993,4]]}}}