{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T23:56:16Z","timestamp":1790207776757,"version":"4.1.0"},"reference-count":42,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors tested the hypothesis that cerebral blood flow (CBF) reactivity to CO<jats:sub>2<\/jats:sub> was blunted following subarachnoid hemorrhage (SAH). Subarachnoid hemorrhage was produced in five cats by performing four cisterna magna injections of blood in each (SAH Group). A second group of six cats was treated with an antifibrinolytic agent (AF) in addition to four cisterna magna blood injections (SAH + AF Group). Four cats received AF and four cisterna magna injections of saline (Control Group). The presence or absence of basilar artery vasospasm was determined by comparing baseline and follow-up selective angiograms. Cerebral blood flow reactivity was determined by randomly varying the concentration of inspired CO<jats:sub>2<\/jats:sub> to alter PaCO<jats:sub>2<\/jats:sub> from 20 to 75 mm Hg. Regional CBF was measured with radiolabeled microspheres. Basilar artery vasospasm was seen following subarachnoid injection of blood but not of saline. Normocapnic CBF was similar in all three groups in the brain stem (mean \u00b1 standard error of the mean: SAH Group 46 \u00b1 6, SAH + AF Group 46 \u00b1 6, and Control Group 44 \u00b1 9 ml\/min\/100 gm) and in the supratentorial compartment (SAH Group 53 \u00b1 8, SAH + AF Group 61 \u00b19, and Control Group 51 \u00b1 13 ml\/min\/100 gm). At intermediate levels of hypercarbia (PaCO<jats:sub>2<\/jats:sub> 50 \u00b1 3 mm Hg), CBF increased similarly in all three groups (SAH Group 161% \u00b1 32%, SAH + AF Group 118% \u00b1 33%, and Control Group 174% \u00b1 19% compared to baseline); at higher levels of PaCO<jats:sub>2<\/jats:sub> (60 \u00b1 3 mm Hg), CBF values were SAH Group 265% \u00b1 50%, SAH + AF Group 205% \u00b1 47%, and Control Group 159% \u00b1 30% of baseline. At the highest level of PaCO<jats:sub>2<\/jats:sub> (75 \u00b1 6 mm Hg), supratentorial CBF did not increase as much in the SAH + AF Group as in the Control Group (179% \u00b1 59% vs. 463% \u00b1 58% of baseline, respectively). The authors conclude that, in this model of SAH, there is no change in normocapnic CBF; however, blood flow reactivity to hypercarbia is blunted. It is possible that this may result from a combination of narrowing of proximal large vessels and globally impaired reactivity of small vessels.<\/jats:p>","DOI":"10.3171\/jns.1993.78.6.0915","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T14:58:28Z","timestamp":1243436308000},"page":"915-921","source":"Crossref","is-referenced-by-count":18,"title":["Altered cerebrovascular CO2 reactivity following subarachnoid hemorrhage in cats"],"prefix":"10.3171","volume":"78","author":[{"given":"Michael N.","family":"Diringer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey R.","family":"Kirsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel F.","family":"Hanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Traystman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","series-title":"J Neurosurg","first-page":"351","article-title":"Vasoconstrictive effects of human post-hemorrhagic cerebrospinal fluid on cat pial arterioles in situ.","volume":"54","author":"Brandt","year":"1981"},{"key":"b2","series-title":"J Neurosurg","first-page":"789","article-title":"Effect of intrathecal fibrinolysis on cerebrospinal fluid absorption after experimental subarachnoid hemorrhage.","volume":"74","author":"Brinker","year":"1991"},{"key":"b3","series-title":"J Neurosurg","first-page":"712","article-title":"Effect of subarachnoid hemorrhage on intracranial pulse waves in cats.","volume":"69","author":"Cardoso","year":"1988"},{"key":"b4","series-title":"J Cereb Blood Flow Metab","first-page":"837","article-title":"Cerebral oxygen metabolism after aneurysmal subarachnoid 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