{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,3,19]],"date-time":"2023-03-19T21:40:08Z","timestamp":1679262008138},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,6]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Secondary non-Hodgkin's lymphoma of the central nervous system is typically a late manifestation of systemic T-cell lymphoma, with a 2-month median survival time after the development of neurological disease. Of the reported patients with this late complication, only 1% manifest spread of the disease to the brain parenchyma. The authors report a patient with an unusual initial neurological presentation of systemic T-cell lymphoproliferative disorder and associated space-occupying lesions of the brain parenchyma. The diagnosis was supported by extensive molecular, immunological, and histopathological analysis. Neurological symptoms appeared early in the course of systemic disease and were characterized by spontaneous exacerbations and remissions. The patient has survived for more than 5 years since the onset of his neurological symptoms. Histopathological characterization including immunoperoxidase staining for T-cell markers, DNA content, and cell-cycle analysis of brain tissue obtained at stereotactic biopsy were compared to those of atypical lymphoid cells of peripheral blood, bone marrow, and liver. The neurological manifestations and possible etiologies of T-cell lymphoma are discussed.<\/jats:p>","DOI":"10.3171\/jns.1993.78.6.0997","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T14:58:28Z","timestamp":1243436308000},"page":"997-1001","source":"Crossref","is-referenced-by-count":3,"title":["Systemic T-cell lymphoma presenting with isolated neurological dysfunction and intraparenchymal brain lesions"],"prefix":"10.3171","volume":"78","author":[{"given":"Martin D.","family":"Herman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo I.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Kaul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Variakojis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1","series-title":"Principles of Neurology","first-page":"707","author":"Adams","year":"1985"},{"key":"b2","series-title":"N Engl J Med","first-page":"529","article-title":"Rearrangement of the gene for the beta chain of the T-cell receptor in T-cell chronic lymphocytic leukemia and related disorders.","volume":"313","author":"Aisenberg","year":"1985"},{"key":"b3","series-title":"Cancer Res","first-page":"3982","article-title":"Row cytometry in clinical cancer research.","volume":"43","author":"Barlogie","year":"1983"},{"key":"b4","series-title":"Acta Neurol Scand","first-page":"602","article-title":"Primary non-Hodgkin's lymphomas of the CNS.","volume":"73","author":"Bogdahn","year":"1986"},{"key":"b5","series-title":"Blood","first-page":"3","article-title":"Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited.","volume":"47","author":"Bunn","year":"1976"},{"key":"b6","series-title":"Surgical Pathology of the Nervous System and Its Coverings","first-page":"359","author":"Burger","year":"1991"},{"key":"b7","series-title":"Arch Pathol Lab Med","first-page":"897","article-title":"Primary cerebral lymphoma. 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