{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T12:10:27Z","timestamp":1785499827645,"version":"3.56.0"},"reference-count":57,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1993,9]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 It has recently been reported that pretreatment with a single dose of dexamethasone (0.1 mg\/kg) 24 hours before hypoxia in 7-day-old rat pups is protective against an hypoxic-ischemic insult (unilateral carotid artery occlusion followed by 3 hours of hypoxia in 8% O<jats:sub>2<\/jats:sub>). The authors now examine whether pretreatment 6 hours before insult is equally effective and compare other agents potentially suitable for prophylaxis in neonatal hypoxia-ischemia, including the calcium antagonists flunarizine (30 mg\/kg pretreatment), nimodipine (0.5 mg\/kg pretreatment), and the 21-aminosteroid U-74389F (10 mg\/kg pre- and posttreatment). For each active agent, there was also a vehicle-treated control group.<\/jats:p><jats:p content-type=\"fine-print\">Comparison of the mean area of ipsilateral infarction on brain coronal sections showed that there was no statistically significant difference between the various control groups (mean area of infarction 66% \u00b1 4%). Pretreatment with dexamethasone 6 hours prior to hypoxia offered complete protection with no infarction. A beneficial effect was seen following pretreatment with flunarizine (mean area of infarction 33.6% \u00b1 7.8%), although this degree of damage was still significantly different from that seen with dexamethasone pretreatment. Pretreatment with nimodipine or U-74389F offered no protection (mean area of infarction 77.5% \u00b1 4% and 59% \u00b1 10%, respectively). Unlike findings in adult animals and clinical studies, the current studies show that dexamethasone may have a role in the treatment of neonatal hypoxia-ischemia and deserves reappraisal.<\/jats:p>","DOI":"10.3171\/jns.1993.79.3.0414","type":"journal-article","created":{"date-parts":[[2009,5,27]],"date-time":"2009-05-27T15:03:16Z","timestamp":1243436596000},"page":"414-420","source":"Crossref","is-referenced-by-count":50,"title":["A comparison of the protective effect of dexamethasone to other potential prophylactic agents in a neonatal rat model of cerebral hypoxia-ischemia"],"prefix":"10.3171","volume":"79","author":[{"given":"Paul D.","family":"Chumas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Del Bigio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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