{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T05:41:03Z","timestamp":1788241263613,"version":"build-2803163510"},"reference-count":45,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors investigated the roles of endothelin (ET)-1 and the ET<jats:sub>A<\/jats:sub> receptor in the pathogenesis of delayed cerebral vasospasm following subarachnoid hemorrhage (SAH). A study was made of the preventive effect of a novel ET<jats:sub>A<\/jats:sub> receptor antagonist, BQ-123, on vasospasm and the expression of the ET<jats:sub>A<\/jats:sub> receptor messenger ribonucleic acid (mRNA) using a canine two-hemorrhage SAH model. Continuous intrathecal administration of BQ-123 (5 \u00d7 10<jats:sup>\u22126<\/jats:sup> mol\/day) prevented narrowing of the basilar artery on Day 7 after SAH in 97.6% of cases in the study group versus 70.7% of cases in the control group (p &lt; 0.05). While expression of the mRNA-coding ET<jats:sub>A<\/jats:sub> receptor was not detected in the control animals, it markedly increased on Day 3 after SAH and was also detected on Day 7. The results suggest that endothelin-1 and the ET<jats:sub>A<\/jats:sub> receptor participate in the pathogenesis of delayed cerebral vasospasm following SAH.<\/jats:p>","DOI":"10.3171\/jns.1994.81.5.0759","type":"journal-article","created":{"date-parts":[[2009,5,28]],"date-time":"2009-05-28T14:40:56Z","timestamp":1243521656000},"page":"759-764","source":"Crossref","is-referenced-by-count":80,"title":["Prevention of delayed vasospasm by an endothelin ETA receptor antagonist, BQ-123: change of ETA receptor mRNA expression in a canine subarachnoid hemorrhage model"],"prefix":"10.3171","volume":"81","author":[{"given":"Shouichi","family":"Itoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomio","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Asai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Kuchino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/348730a0","volume":"348","author":"Arai H","year":"1990","journal-title":"Nature"},{"key":"b2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(89)92258-4"},{"key":"b3","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/0006-291X(89)92636-3","volume":"161","author":"Cernacek P","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"b4","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"b5","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3171\/jns.1984.60.2.0335","volume":"60","author":"Doczi T","year":"1986","journal-title":"J Neurosurg"},{"key":"b6","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1992.76.5.0830"},{"key":"b7","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.172.6.1741","volume":"172","author":"Ehrenreich H","year":"1990","journal-title":"J Exp Med"},{"key":"b8","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198911000-00008"},{"key":"b9","first-page":"1686","volume":"321","author":"Hirata Y","year":"1989","journal-title":"N Engl J Med"},{"key":"b10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0014-5793(88)80536-2","volume":"239","author":"Hirata Y","year":"1988","journal-title":"FEBS Lett"},{"key":"b11","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.69.2.0247"},{"key":"b12","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0014-5793(91)80007-P","volume":"287","author":"Hosoda K","year":"1991","journal-title":"FEBS Lett"},{"key":"b13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1978.48.4.0515"},{"key":"b14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/01616412.1989.11739870","volume":"11","author":"Ide K","year":"1989","journal-title":"Neurol Res"},{"key":"b15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0024-3205(92)90331-I","volume":"50","author":"Ihara M","year":"1992","journal-title":"Life Sci"},{"key":"b16","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1073\/pnas.86.8.2863","volume":"86","author":"Inoue A","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.16.4.562"},{"key":"b18","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.69.2.0239"},{"key":"b19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0014-5793(88)80489-7","volume":"238","author":"Komuro I","year":"1988","journal-title":"FEBS Lett"},{"key":"b20","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.1073\/pnas.88.8.3185","volume":"88","author":"Lin HY","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"b21","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1981.55.5.0779"},{"key":"b22","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/S0140-6736(89)92019-9","volume":"2","author":"Masaoka H","year":"1989","journal-title":"Lancet"},{"key":"b23","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(91)90249-B"},{"key":"b24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0140-6736(89)90303-6","volume":"2","author":"Miyauchi T","year":"1989","journal-title":"Lancet"},{"key":"b25","doi-asserted-by":"crossref","first-page":"967","DOI":"10.2176\/nmc.29.967","volume":"29","author":"Nakagomi T","year":"1989","journal-title":"Neurol Med Chir"},{"key":"b26","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/01.STR.18.2.482","volume":"18","author":"Nakagomi T","year":"1987","journal-title":"Stroke"},{"key":"b27","first-page":"242","volume-title":"Cerebral Vasospasm. 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