{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:36:33Z","timestamp":1789716993766,"version":"4.0.1"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 Tenascin is an extracellular matrix glycoprotein expressed during both normal development and neoplastic growth in both neural and nonneural tissues. During development of the central nervous system (CNS), tenascin is synthesized by glial cells, in particular by immature astrocytes, and is concentrated in transient boundaries around emerging groups of functionally distinct neurons. In the mature CNS, only low levels of the glycoprotein can be detected. The present study demonstrates that following trauma to the adult human cerebral cortex, discrete populations of reactive astrocytes upregulate their expression of tenascin and dramatically increase their transcription of the tenascin gene. The enhanced expression of tenascin may be involved in CNS wound healing, and may also affect neurite growth within and around a brain lesion.<\/jats:p>","DOI":"10.3171\/jns.1995.82.1.0106","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T18:00:40Z","timestamp":1243965640000},"page":"106-112","source":"Crossref","is-referenced-by-count":86,"title":["Focal brain injury and upregulation of a developmentally regulated extracellular matrix protein"],"prefix":"10.3171","volume":"82","author":[{"given":"Jason A.","family":"Brodkey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Laywell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"O'Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Faissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari","family":"Stefansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Ulrich","family":"D\u00f6rries","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melitta","family":"Schachner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis A.","family":"Steindler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1523\/JNEUROSCI.12-03-00736.1992","volume":"12","author":"Bartsch S","year":"1992","journal-title":"J Neurosci"},{"key":"b2","first-page":"2796","volume":"43","author":"Bourdon MA","year":"1983","journal-title":"Cancer Res"},{"key":"b3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1006\/exnr.1993.1158","volume":"123","author":"Brodkey JA","year":"1993","journal-title":"Exp Neurol"},{"key":"b4","first-page":"427","volume":"138","author":"Chuong CM","year":"1991","journal-title":"Am J Pathol"},{"key":"b5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0006-8993(93)90415-J","volume":"600","author":"da Cunha A","year":"1993","journal-title":"Brain Res"},{"key":"b6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev.cb.05.110189.000443","volume":"5","author":"Erickson HP","year":"1989","journal-title":"Annu Rev Cell Biol"},{"key":"b7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0896-6273(90)90217-4","volume":"5","author":"Faissner A","year":"1990","journal-title":"Neuron"},{"key":"b8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1432-0436.1988.tb00802.x","volume":"37","author":"Faissner A","year":"1988","journal-title":"Differentiation"},{"key":"b9","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1073\/pnas.86.5.1588","volume":"86","author":"Gulcher JR","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"b10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/0012-1606(89)90200-5","volume":"132","author":"Halfter W","year":"1989","journal-title":"Dev Biol"},{"key":"b11","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1083\/jcb.116.6.1475","volume":"116","author":"Husmann K","year":"1992","journal-title":"J Cell Biol"},{"key":"b12","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/0046-8177(91)90285-W","volume":"22","author":"Koukoulis GK","year":"1991","journal-title":"Hum Pathol"},{"key":"b13","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1073\/pnas.89.7.2634","volume":"89","author":"Laywell ED","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"b14","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1083\/jcb.117.2.395","volume":"117","author":"Lindholm D","year":"1992","journal-title":"J Cell Biol"},{"key":"b15","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1083\/jcb.113.5.1159","volume":"113","author":"Lochter A","year":"1991","journal-title":"J Cell Biol"},{"key":"b16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0006-8993(92)91000-5","volume":"587","author":"Logan A","year":"1992","journal-title":"Brain Res"},{"key":"b17","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1083\/jcb.107.6.2757","volume":"107","author":"Mackie EJ","year":"1988","journal-title":"J Cell Biol"},{"key":"b18","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1523\/JNEUROSCI.11-11-03398.1991","volume":"11","author":"McKeon RJ","year":"1991","journal-title":"J Neurosci"},{"key":"b19","first-page":"331","volume-title":"Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injury.","author":"Nieto-Sampedro M","year":"1988"},{"key":"b20","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1002\/j.1460-2075.1988.tb03160.x","volume":"7","author":"Pearson CA","year":"1988","journal-title":"EMBO J"},{"key":"b21","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1126\/science.1843843","volume":"252","author":"Pons TP","year":"1991","journal-title":"Science"},{"key":"b22","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1089\/neu.1992.9.73","volume":"9","author":"Povlishock JT","year":"1992","journal-title":"J Neurotrauma"},{"key":"b23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/j.1471-4159.1990.tb02351.x","volume":"54","author":"Probstmeier R","year":"1990","journal-title":"J Neurochem"},{"key":"b24","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1126\/science.1439826","volume":"258","author":"Ramachandran VS","year":"1992","journal-title":"Science"},{"key":"b25","volume-title":"Degeneration and Regeneration of the Nervous System.","author":"Ramon y Cajal S","year":"1928"},{"key":"b26","first-page":"163","volume-title":"Spinal Cord Reconstruction.","author":"Reier PJ","year":"1983"},{"key":"b27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.ne.16.030193.003025","volume":"16","author":"Schwab ME","year":"1993","journal-title":"Annu Rev Neurosci"},{"key":"b28","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-4886(05)80013-5"},{"key":"b29","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev.ne.16.030193.002305","volume":"16","author":"Steindler DA","year":"1993","journal-title":"Annu Rev Neurosci"},{"key":"b30","first-page":"1042","volume":"18","author":"Steindler DA","year":"1992","journal-title":"Soc Neurosci Abstracts"},{"key":"b31","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1089\/neu.1989.6.99","volume":"6","author":"Steward O","year":"1989","journal-title":"J Neurotrauma"},{"key":"b32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/jnr.490350402","volume":"35","author":"Taylor J","year":"1993","journal-title":"J Neurosci Res"},{"key":"b33","first-page":"2912","volume":"32","author":"Tervo K","year":"1991","journal-title":"Invest Ophthal Vis Sci"},{"key":"b34","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1242\/dev.112.4.1031","volume":"112","author":"Tucker RP","year":"1991","journal-title":"Development"},{"key":"b35","doi-asserted-by":"publisher","DOI":"10.1098\/rstl.1850.0021"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/82\/1\/article-p106.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/82\/1\/article-p106.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/82\/1\/article-p106.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T05:50:19Z","timestamp":1652507419000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/82\/1\/article-p106.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":35,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/jns.1995.82.1.0106","relation":{},"ISSN":["0022-3085"],"issn-type":[{"value":"0022-3085","type":"print"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}