{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T09:39:50Z","timestamp":1773308390847,"version":"3.50.1"},"reference-count":59,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,6]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 A traumatic cerebral contusion causes a zone of perifocal neuronal necrosis, the cause of which is not known; the surgical management of these lesions remains controversial. To determine the pathophysiological mechanisms responsible for brain damage after contusions, the authors performed cerebral blood flow (CBF) mapping studies and related these to change in local cerebral blood volume (CBV) and ultrastructure. In 11 severely head injured patients with contusion, CBF and CBV were measured in pericontusional areas using stable xenon-computerized tomography (CT). These studies demonstrated a profound reduction in perilesional CBF (mean 17.5 \u00b1 4 ml\/100 g\/min), which was always accompanied by a zone of edema defined by CT density measurements. Mean CBV in these regions was 2.3 \u00b1 0.4 ml\/100 g, a reduction to approximately one-half the value of 4.8 ml\/100 g found in the nonedematous regions, and to approximately 35% of the value of 6.0 ml\/100 g found in normal volunteers. Ultrastructural analysis of the pericontusional tissue, taken at surgery in four patients with high intracranial pressure showed glial swelling with narrowing of the microvascular lumina due to massive podocytic process swelling. Additionally, some suggestion of vascular occlusion due to erythrocyte and leukocyte stasis was seen. These data support the conclusion that microvascular compromise by compression and\/or occlusion is a major event associated with profound perilesional hypoperfusion, which is a uniform finding within edematous pericontusional tissue.<\/jats:p>","DOI":"10.3171\/jns.1995.82.6.0966","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T17:00:48Z","timestamp":1243962048000},"page":"966-971","source":"Crossref","is-referenced-by-count":133,"title":["Focal ischemia due to traumatic contusions documented by stable xenon-CT and ultrastructural studies"],"prefix":"10.3171","volume":"82","author":[{"given":"Marc L.","family":"Schr\u00f6der","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Paul","family":"Muizelaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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