{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T22:10:02Z","timestamp":1739139002985,"version":"3.37.0"},"reference-count":49,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The smooth-muscle relaxant action of adenosine 5\u2032-triphosphate (ATP)-sensitive potassium (K<jats:sub>ATP<\/jats:sub>) channels in cerebral arteries of large diameter has been confirmed in a number of<jats:italic>in vitro<\/jats:italic>studies, but there is still debate about the presence of K<jats:sub>ATP<\/jats:sub>channels in small cerebral arteries. In the present study, the authors compare the effects of cromakalim and bimakalim, two putative K<jats:sub>ATP<\/jats:sub>channel activators, in different parts of the feline isolated middle cerebral artery (MCA) designated proximal, intermediate, and distal. The latter corresponds to those small pial arteries that are usually studied<jats:italic>in vivo<\/jats:italic>. In ring segments precontracted with 10<jats:sup>\u22125<\/jats:sup>M of uridine-5-triphosphate (UTP), both cromakalim and bimakalim induced concentration-related relaxation, with bimakalim being more potent than cromakalim, and no significant differences noted among segments obtained from the different regions of the MCA. In vessels precontracted by adding 30 mM KCl the potency of cromakalim and bimakalim was reduced compared with that obtained after UTP precontraction. In the presence of 10<jats:sup>\u22126<\/jats:sup>M glibenclamide, an antagonist of K<jats:sub>ATP<\/jats:sub>channel activators, the concentration\u2014effect curve to bimakalim was shifted to the right in the proximal and distal MCA, indicating a similar route of action for bimakalim and cromakalim in these arteries. The present study therefore indicates the presence of K<jats:sub>ATP<\/jats:sub>channels in isolated small cerebral arteries according to results obtained<jats:italic>in vivo<\/jats:italic>. Activators of K<jats:sub>ATP<\/jats:sub>channels may prove helpful in the treatment of vasospasm, which may occur in large and small cerebral arteries after subarachnoid hemorrhage.<\/jats:p>","DOI":"10.3171\/jns.1995.83.1.0123","type":"journal-article","created":{"date-parts":[[2009,6,2]],"date-time":"2009-06-02T17:41:35Z","timestamp":1243964495000},"page":"123-128","source":"Crossref","is-referenced-by-count":9,"title":["Effects of potassium channel activators on isolated cerebral arteries of large and small diameter in the cat"],"prefix":"10.3171","volume":"83","author":[{"given":"Lothar","family":"Schilling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew 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