{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:59:22Z","timestamp":1788526762714,"version":"build-2803163510"},"reference-count":85,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p content-type=\"fine-print\">\u2713 The authors report findings from a metaanalysis of all published randomized trials of prophylactic nimodipine used in patients who have experienced subarachnoid hemorrhage (SAH). Seven trials were included with a total of 1202 patients suitable for evaluation. Eight outcome measures were examined, including good versus other outcome, good or fair outcome versus other outcome, overall mortality, deficit and\/or death attributed to vasospasm, infarction rate as judged by computerized tomography (CT), and deficit and\/or death from rebleeding.<\/jats:p>\n<jats:p content-type=\"fine-print\">Nimodipine improved outcome according to all measures examined. The odds of good and of good plus fair outcomes were improved by ratios of 1.86:1 and 1.67:1, respectively, for nimodipine versus control (p &lt; 0.005 for both measures). The odds of deficit and\/or mortality attributed to vasospasm and CT-assessed infarction rate were reduced by ratios of 0.46:1 to 0.58:1 in the nimodipine group (p &lt; 0.008 for all measures). Overall mortality was slightly reduced in the nimodipine group, but the trend was not statistically significant. The rebleeding rate was not increased by nimodipine. A metaregression yielded findings indicating that the treatment effect of nimodipine in individual trials was positively correlated with the severity of SAH in enrolled patients.<\/jats:p>\n<jats:p content-type=\"fine-print\">Although the majority of individual trials examined did not have statistically significant results at the p &lt; 0.01 level according to most outcome measures, the metaanalyses confirmed the significant efficacy of prophylactic nimodipine in improving outcome after SAH under the conditions used in these trials.<\/jats:p>","DOI":"10.3171\/jns.1996.84.3.0405","type":"journal-article","created":{"date-parts":[[2009,6,8]],"date-time":"2009-06-08T23:42:43Z","timestamp":1244504563000},"page":"405-414","source":"Crossref","is-referenced-by-count":278,"title":["Efficacy of prophylactic nimodipine for delayed ischemic deficit after subarachnoid hemorrhage: a metaanalysis"],"prefix":"10.3171","volume":"84","author":[{"given":"Fred 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